Role of circulating serum YKL-40 level in assessment of severity in hypersensitivity pneumonitis patients | ||
| International Journal of Health Sciences (Egypt) | ||
| Volume 1, Issue 1, April 2023, Pages 8-17 PDF (460.3 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijhegy.2023.196687.1006 | ||
| Authors | ||
| hala ashraf* 1; Nasser Keshar2; Irene Sabry3; heba sharaf4; amr ashraf3; youssef soliman3 | ||
| 1department of clinical and chemical pathology Cairo university kasr el ainy | ||
| 2Chest diseases, Cairo University | ||
| 3chest diseases Cairo university | ||
| 4clinical and chemical pathology cairo university | ||
| Abstract | ||
| BACKGROUND: Hypersensitivity pneumonitis (HP) is a diffuse parenchymal lung disease characterized by immune-mediated inflammation of lung parenchyma triggered by exposure to a wide variety of inhaled antigens. YKL-40 plays a fundamental role in protecting against pathogens, antigen-induced and oxidant-induced injury responses, inflammation, and tissue repair and remodeling. This is achieved by regulating many biological processes.OBJECTIVE: The aim of this study was to evaluate the YKL-40 serum level as a possible biomarker for disease activity in hypersensitivity pneumonitis. METHODS: The study included 25 patients who were diagnosed primarily as hypersensitivity pneumonitis in Chest Department, Faculty of Medicine, Cairo University from April 2021 to August 2021. Moreover, 25 healthy age- and sex-matched controls were enrolled.RESULTS: YKL-40 was significantly higher among HP group, in fibrotic more that non-fibrotic subtype. YKL-40 had a negative correlation with oxygen saturation (SaO2) on room air, minimum SO2 in 6MWT and distance in 6MWT in HP patients. In addition, YKL-40 has a positive correlation with dyspnea score in HP patients. The fibrotic subgroup, compared to non-fibrotic subgroup had significantly higher serum YKL-40 level. A cut-off value of 629.4 pg/ml for serum YKL-40 level can distinguish between the HP patients and normal individuals (sensitivity =96%, and specificity =96%). Moreover, a cut-off value of 1181.5 pg/ml for serum YKL-40 level can distinguish between the fibrotic and non-fibrotic HP sub-types (sensitivity =85.7%, and specificity =81.8%).CONCLUSION: YKL-40 is a useful prognostic marker for hypersensitivity pneumonitis and can help in discriminating between fibrotic and non-fibrotic subtypes. | ||
| Keywords | ||
| Hypersensitivity pneumonitis; YKL-40; Biomarker; Fibrosis; Assessment of severity | ||
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