Prevalence of Asthma in Children with Autism and Attention Deficit Hyperactivity Disorder | ||
| International Journal of Medical Arts | ||
| Article 6, Volume 4, Issue 12, December 2022, Pages 2891-2905 PDF (1.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2023.194142.1625 | ||
| Authors | ||
| Aisha Ghanem Abd El Lateef* 1; Shaymaa Mohammed Arafa2; Medhat Mohamed Abdelsalam Darwish3; Mohamed Soliman Hassan Zaki4; Hanana Abdelkader Ahmed Atta5 | ||
| 1Department of Psychiatry, Faculty of Medicine [for Girls], Al-Azhar University, Cairo, Egypt. | ||
| 2Department of Psychiatry, Faculty of Medicine [for Girls], Al-Azhar University, Cairo, Egypt | ||
| 3Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||
| 4Department of Chest Diseases, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||
| 5Department of Child Health, National Research Centre, Giza. | ||
| Abstract | ||
| Background: Inflammatory reaction and asthma in certain children with features of autism spectrum disorders (ASD) as well as attention-deficit hyperactivity disorder (ADHD) have been reported previously. Aim of the Work: Our primary goal in conducting this study was to look into how childhood asthma and attention deficit hyperactive disorder and childhood autism are related. Patients and Methods: Childhood ASD and ADHD patients' peripheral immune cells were removed, and after ex vivo mitogens were activated, the generation of the cytokines IL-17, IL-13 and IL-4 was evaluated. All ASD and ADHD individuals fulfilled the requirements for identification according to the Diagnostic and Statistical Manual of Mental Disorders, fifth Edition (DSM-V). The level of autism was assessed using the Childhood Autism Rating Scale (CARS). In order to ascertain the correlation between asthma and ADHD symptoms, generalized estimating equations were employed. Results: Importantly, in contrast to children with ASD as well as ADHD produced considerably more IL-17 after stimulation. Additionally, individuals with ASD, ADHD and co-morbid asthma had higher levels of IL-17. Conclusion: When T cells were stimulated, children with ASD and ADHD responded differently producing more IL-17. | ||
| Keywords | ||
| ADHD; Asthma; Autism; Food allergies; IL-17 | ||
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