Apoptosis in cancer: from pathogenesis to discovery of advanced selective Bcl-2 family inhibitors | ||
| Archives of Pharmaceutical Sciences Ain Shams University | ||
| Article 4, Volume 3, Issue 1, January 2019, Pages 37-54 PDF (1.02 M) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/aps.2019.20225 | ||
| Authors | ||
| Samaa Abbas* 1; Nermin S. Abdou2; Deena S. Lasheen3; Dalal A. Abou El Ella4 | ||
| 1Pharmaceutical Chemistry, Faculty of Pharmacy, ASU, Cairo, Egypt | ||
| 2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt | ||
| 3Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo11566, Egypt | ||
| 4Pharmaceutical Chemistry Department, Faculty of Pharmacy, El-Nahda University, Beni sweif, Egypt | ||
| Abstract | ||
| Cancer is a genetic disease characterized by two features: unregulated cell growth and tissue invasion (metastasis). It can be viewed as the result of a succession of genetic changes during which a normal cell is transformed into a malignant one. Evasion of cell death, apoptosis, is one of the essential changes in a cell that cause this malignant transformation. Hence, reduced apoptosis or its resistance plays a vital role in carcinogenesis. The Bcl-2 family of proteins regulates the mitochondrial apoptotic pathway. Disease states arise upon deregulation of the Bcl-2 family of proteins, where cell death is either promoted or evaded; one of the most common tactic cancer cells utilize to promote survival is anti-apoptotic protein overexpression. Specifically, Bcl-2 overexpression has been shown to be a major chemoresistance factor in a number of human cancers, and for this reason, Bcl-2 targeting is a pharmacologic priority in the quest to reactivate cell death for therapeutic benefit in cancer. | ||
| Keywords | ||
| apoptosis; Bcl-2; Extrinsic pathway; Intrinsic pathway; Caspase; BH3 | ||
| References | ||
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