Comparative toxicological studies of some food additives on foetal development in rats | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 11, November 2023, Pages 597-610 PDF (548.24 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.190987.7539 | ||
| Authors | ||
| Mohamed Fayed Abdelhameed1; Ahmed NAGY MOHAMED Ahmed2; shereif salah Mohamed* 3 | ||
| 1Pharmacology department, medical division, national research centre | ||
| 2National Research Center | ||
| 3department of nutrition and food science, NRC, Egypt | ||
| Abstract | ||
| This study aimed to compare the impact of some common food additives (MSG, ACK, BHA and BHT) on fetal development. To do this, forty female albino rats weighing approximately 200g were examined to determine their estrous period and then paired with appropriate fertile males. The effects of these food additives on fetal development were then monitored throughout the remainder of the pregnancy period. On the sixth day of pregnancy, the pregnant rats were divided into five different groups: Group A (control) received saline, while Groups B-E received MSG, ACK, BHA and BHT respectively in doses of 3, 15, 25 and 14 mg kg-1 day-1. Upon morphological, visceral and skeletal examination of the fetuses, it was concluded that the food additives had a significant negative impact on fetal development. Therefore, it is advised that consumers should avoid consuming food additives during this period of gestation. | ||
| Keywords | ||
| Food additives; teratogenicity; sweeteners; MSG; fetal development | ||
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