Strategies to Improve solubility of Oral Drugs | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Volume 7, Issue 3, January 2023, Pages 1-14 PDF (859.6 K) | ||
| Document Type: Mini-reviews | ||
| DOI: 10.21608/rpbs.2022.169532.1182 | ||
| Authors | ||
| Mohammed Nabil El Tahan1; Taha Mohamed Hammady2; Mohamed Saleh Elgawish3; Shadeed Gad* 4 | ||
| 1pharmaceutics department, faculty of pharmacy, Suez canal university, Ismailia, Egypt | ||
| 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University | ||
| 3Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia (41522), Egypt | ||
| 4Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt | ||
| Abstract | ||
| One of the most common routes for drug administration is the oral route. It has many advantages like patient compliance, non-invasiveness and drug administration convenience. Oral administration accounts for over 60% of all established small-molecule medication products on the market. Oral drug absorption may be governed by many factors such as mucosal permeability, drug solubility and stability in the gastrointestinal tract. The trials to overcome these factors depend on understanding the biochemical, physicochemical, biological and metabolic barriers which affect the overall bioavailability of a drug. Enhancement of oral drug absorption can be achieved by many drug delivery systems and pharmaceutical technologies such as lipid-based carriers, micelles, nanocarriers, salt formation, solid dispersion, and complexation techniques using cyclodextrins. The strategies to improve the oral drug delivery will be discussed in details especially cyclodextrin complexation which is considered one of the most common strategies having great role in enhancing the oral drug delivery. | ||
| Keywords | ||
| Oral drugs; solubility; complexation; cyclodextrins | ||
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