Effect of Nano Fat Graft on the Healing of Donor Site of Split Thickness Skin Graft | ||
| The Egyptian Journal of Plastic and Reconstructive Surgery | ||
| Article 2, Volume 47, Issue 2, April 2023, Pages 79-88 PDF (20.65 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/ejprs.2023.291375 | ||
| Authors | ||
| Khaled ElSherbeny* ; Ahmed Elshahat; Ahmed M Gad | ||
| The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Ain Shams University | ||
| Abstract | ||
| Background: Split-thickness grafts (STSGs) harvesting is a common technique to reconstruct absent skin and to reestablish the skin barrier in burn and skin defects. Donor site morbidity is not uncommon. Various materials and dressings had been used to improve healing of donor site. Fat grafting or its components had been used in promotion of healing in chronic and irradiated wounds indicating the possibility of improving healing. Objective: To evaluate the effect of adding nano fat grafts to donor sites of STSGs. Patients and Methods: Twenty (20) adult patients were included in this comparative self-controlled clinical trial from March 2020 to April 2021. These patients had raw areas of skin needing STSG. STSG thickness was 0.12.5 inch leaving an area measuring 7x15cm (105cm2) at the donor site. The donor site area in the lower limb was used as a test area where it was divided into two equal areas, one area was covered by nano fat graft and Vaseline gauze (group A), the other acting as a control group was covered by Vaseline gauze only (group < br />B). Group A was compared to group B as regard healing time from 10th day onward and quality of healing after one month using Vancouver scale (VSS). Tissue biopsy was taken at day 21 from both groups. Any Donor site complications were noted. Results: Comparing The rate of donor site healing in group A with group B, group A showed faster healing with a mean of (13.30±2.61) versus (16.05±2.43) days from the date of harvesting of STSG. Histologically the mean thickness of neo epithelium in group A was more than that of group B with a mean value of 255.04±15.27mm and 161.15±28.75mm consecutively. Group A showed better vascularity and pliability while no difference was detected as regard pigmentation and height. Infection occurred in donor site of one patient. Conclusions: Using topical nano fat graft and Vaseline gauze on the donor site of STSG improves healing time as well as vascularity and pliability in comparison to Vaseline gauze alone. | ||
| Keywords | ||
| Donor site; Split thickness skin graft; Nano fat graft; Vancouver scar scale | ||
| References | ||
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