Evaluation of the Level of Interleukins 13 and 33 in the Serum of Patients with Renal Failure in Kirkuk City | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 222, Volume 90, Issue 2, January 2023, Pages 3454-3457 PDF (328.37 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2023.291461 | ||
| Authors | ||
| Muthana N. Abdullai* ; Hayfaa M. Fahad; Mohammed H. Mushrif | ||
| Abstract | ||
| Background: A poor prognosis and a high death rate are associated with chronic progressive renal loss of parenchymal function. Objective: This study aimed to ascertain the relationship between interleukin (IL)-13 and IL-33 and kidney failure and their function as inflammatory markers. Patients and methods: Study participants ranged in age from 17 to 75 and were admitted to the Dialysis Unit of Kirkuk General Hospital. They included 45 clinically diagnosed patients (15 patients with Candida albicans infection and 30 without infection), and 45 healthy controls. Immunological tests of IL-33 and IL-13 were done using ELISA. Results: The mean value of IL-13 was significantly higher among the cases group than in the control group (184.08 ± 60.79 vs 120.44 ± 22.67, P=0.000). Likewise, the mean level of IL-33 was significantly higher among renal failure patients than those in the renal failure-free group. Conclusions: The present study showed increase in IL33 levels in serum of renal failure patients when compared with the control group. Whereas, the IL13 and IL-33 levels in the serum of renal failure patients with Candida albicans infection were higher than in renal failure patients without Candida albicans. | ||
| Keywords | ||
| Kidney failure; Chronic kidney disease; IL33; IL13; Candida albicans | ||
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