Synthesis, characterization, DNA binding of nano Mn2+and Cu2+complexes | ||
| Research Journal of Applied Biotechnology | ||
| Article 2, Volume 8, Issue 1, June 2022, Pages 11-26 PDF (668.21 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/rjab.2022.292262 | ||
| Authors | ||
| Nashwa Mokhtar Hassan Rizk; Samar A. Aly* ; Manal A. Khidr | ||
| Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City 32958, Egypt. | ||
| Abstract | ||
| New complexes for Mn2+ and Cu2+ were prepared and characterized from ligand, 2-(phenylglycyl)-N-(p-tolyl)hydrazine-1-carbo thioamide (H2L) and binuclear Cu2+ complex (B3) of hydrazone derivatives . The structural compositions of the novel chelates were clarified using spectral, molar conductivity, FTIR, UV-Visible spectra,TGA, XRD and analytical techniques. The outcomes supported the ligand's neutral bidentate or monobasic tridentate behaviour. Coordination bonding has occurred via carbonyl oxygen (C=O) and N(2)H or (C-S) groups in complex (B1). The synthesized mononuclear complexes B1and B2 displayed an octahedral , square planar form . While B3 complex is binuclear . Also, the Cu2+complex (B2) has a stronger antibacterial and anticancer activity than the Mn2+complex and the ligand when tested against different bacterial species and the HepG2 cell line. Respectively; The binding ability of ligand and Cu2+ complex (B2) with CT-DNA was aimed to for being intercelation or alternative strategy. The constant of intrinsic binding Kb was estimated . | ||
| Keywords | ||
| Complexes; DNA binding; Infrared; TGA; Antibacterial | ||
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