Expression of CD86 on Circulating Monocytes in Patients with Alopecia Areata | ||
| Benha Journal of Applied Sciences | ||
| Article 21, Volume 7, Issue 11, November 2022, Pages 123-126 PDF (374.1 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2022.293464 | ||
| Authors | ||
| A.M. Tawfik1; F.M. ELesway1; A.I. Mustafa1; R.H. Sattar2 | ||
| 1Dermatology Venereology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| 2Clinical and Chemical Pathology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| Abstract | ||
| An introductory word on alopecia areata (AA), a disease that causes hair loss without leaving scars. The emotional toll may be high, resulting in melancholy and withdrawal from friends and family. The peak incidence rate occurs between the ages of 30 and 40. Sixty-six percent of patients are under the age of 30, while just twenty percent are 40 or older. Dendritic cells (DCs), macrophages, B-cells, and other antigen-presenting cells produce the protein CD86, also known as cluster of differentiation 86. (APCs). Both CD80 and CD86 are required for T-cell activation and survival by sending out costimulatory signals. CD86 may signal for either upregulation and cell-cell interaction or downregulation and dissociation, depending on the ligand bound. The goal of this study is to examine CD86 expression on circulating monocytes in AA patients and to analyse the potential function of CD86 in the aetiology of AA. Patient and Method Information: Forty alcoholics-in-recovery (AA) participated in this research. Together with a control group of 20 people of same age and gender who all seem to be healthy. All patients enrolled between September 2020 and November 2021 from the Benha University Hospitals' Dermatology, Venereology, and Andrology Department's outpatient clinic. CD 86+ surface expression was substantially greater in individuals with alopecia areata than in the control group (p=0.014). Thus, it is possible that serum CD86 level contributes to AA aetiology. In addition, its expression level may be used as a surrogate marker for AA risk, activity, and severity. Hair pull test, dermoscopy, and similar terms. | ||
| Keywords | ||
| Expression of CD86; Alopecia Areata; marker for AA | ||
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