Carbohydrates and Plant Extracts as Natural Alternatives for Preventing Staphylococcus aureus Biofilm Formation | ||
| Delta Journal of Science | ||
| Article 1, Volume 46, Issue 2, April 2023, Pages 1-16 PDF (532.76 K) | ||
| Document Type: Research and Reference | ||
| DOI: 10.21608/djs.2023.294112 | ||
| Authors | ||
| Sobhy E. Elsilk* ; Mohammed E. Eid | ||
| Abstract | ||
| Staphylococcus aureus is a common bacterial pathogen that can cause various infections, including biofilm-related infections that are difficult to treat. In this study, we investigated the effects of different carbohydrates and plant extracts on the biofilm formation of three standard strains of S. aureus obtained from different sources. We found that the adherence and biofilm formation of the strains were affected by their source, age, and culture conditions. Additionally, we found that Nigella sativa extract and certain monosaccharides, disaccharides, and polysaccharides were effective in reducing biofilm formation, with some degree of strain-specificity. Furthermore, we found that starch had a concentration-dependent effect on the biofilm formation of S. aureus strains. Finally, we investigated the acidogenicity of different carbohydrates in LB broth and found that they were less acidogenic than the control group, but with no significant differences between the strains. Our findings suggest that plant extracts and certain carbohydrates may have the potential as natural alternatives for preventing and treating biofilm-related infections caused by S. aureus. | ||
| Keywords | ||
| Staphylococcus aureus; Biofilmrelated infections; Biofilm formation; Carbohydrates; Plant extracts; Nigella sativa extract | ||
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