Abdulaziz, B., Gad, M., Ghadour, I., Abdellhalim ibrahim, W., S.Elgazar, A. (2023). Serum Uric Acid in Metabolic Associated Fatty Liver Disease in Obese and Lean Patients. test, 40(2), 411-419. doi: 10.21608/bmfj.2023.198873.1779
Badawy Abdulkhalik Abdulaziz; Magdy Abd El Mawgoud Gad; Ibrahim Mohamed Ghadour; Walid Abdellatif Abdellhalim ibrahim; Ahmed S.Elgazar. "Serum Uric Acid in Metabolic Associated Fatty Liver Disease in Obese and Lean Patients". test, 40, 2, 2023, 411-419. doi: 10.21608/bmfj.2023.198873.1779
Abdulaziz, B., Gad, M., Ghadour, I., Abdellhalim ibrahim, W., S.Elgazar, A. (2023). 'Serum Uric Acid in Metabolic Associated Fatty Liver Disease in Obese and Lean Patients', test, 40(2), pp. 411-419. doi: 10.21608/bmfj.2023.198873.1779
Abdulaziz, B., Gad, M., Ghadour, I., Abdellhalim ibrahim, W., S.Elgazar, A. Serum Uric Acid in Metabolic Associated Fatty Liver Disease in Obese and Lean Patients. test, 2023; 40(2): 411-419. doi: 10.21608/bmfj.2023.198873.1779

Serum Uric Acid in Metabolic Associated Fatty Liver Disease in Obese and Lean Patients

Benha Medical Journal
Article 10, Volume 40, Issue 2, September and October 2023, Pages 411-419    PDF (629.34 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.198873.1779
Authors
Badawy Abdulkhalik Abdulaziz1; Magdy Abd El Mawgoud Gad2; Ibrahim Mohamed Ghadour* 3; Walid Abdellatif Abdellhalim ibrahim4; Ahmed S.Elgazar5
1Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Benha University
2Professor of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Benha University
3Department of Hepatology, Gastroenterology And Infectious Diseases Faculty of Medicine - Benha University
4Lecturer of clinical and chemical pathology, Faculty of Medicine, Benha University
5Lecturer of Hepatology, Gastroenterology and Infectious Diseases, , Faculty of Medicine, Benha University
Abstract
Background: Non-alcoholic fatty liver disease or more recently re-defined metabolic associated fatty liver disease (MAFLD) is regarded as the most relevant liver disease of the twenty-first century, affecting at least one third of the general population. This study aimed to study the association between serum uric acid (SUA) and MAFLD in obese and lean patients. Methods: This cross-sectional study was conducted on lean MAFLD patients compared with obese MAFLD patients who attended inpatient and outpatient clinics of Hepatology and Gastroenterology department of Benha University Hospital. Patients were divided into 2 equal groups: Group I: included 45 lean MAFLD patients and Group II: included 45 obese MAFLD patients. Results: Serum creatinine was significantly lower in group I compared to group II (P value =0.001). There was a significant positive correlation between CAP score and Albumin (r=0.222, P=0.036), cholesterol (r=0.333, P=0.001) and serum uric acid (r=0.289, P=0.006). There was a significant positive correlation between serum uric acid and cholesterol (r=0.300, P=0.004), LDL (r=0.301, P=0.00) and CAP score (r=0.289, P=0.006). Conclusion: Our study supports the rationale for serum uric acid (SUA) being established as another risk factor for metabolic dysfunctions in lean/normal-weight and obese MAFLD.
Keywords
Serum Uric Acid; MAFLD; Obese; Lean Patients
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