Performance assessment of StandardTM Q COVID-19 Ag Test in Ouagadougou, Burkina Faso | ||
| Microbes and Infectious Diseases | ||
| Article 2, Volume 4, Issue 3, August 2023, Pages 713-723 PDF (879.62 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2023.205094.1507 | ||
| Authors | ||
| Abdou Azaque Zoure* 1; Henri Gautier Ouedraogo1; Serge Théophile Soubeiga1; Tegwinde Rebeca Compaoré1; Sylvie Zida1; Oumarou Ouedraogo1; Dinanibè Kambiré1; Dezemon Zingue2; Charlemagne Dabiré1; Alidou KAGAMBEGA1; Charles Sawadogo3; Zakariya Yabre3; Tani SAGNA1; Lassana Sangare4 | ||
| 1Département Biomédical et Santé Publique, Institut de Recherche en Sciences de la Santé /National Centre for Scientific and Technologic Research (IRSS/CNRST), Ouagadougou, Burkina Faso | ||
| 2Institut National de Santé Publique (INSP), Ministère de la Santé, Ouagadougou, Burkina Faso | ||
| 3Direction des Laboratoires de Biologie Médicale (DLBM), Ministère de la santé et de l’Hygiène publique, Ouagadougou, Burkina Faso | ||
| 4Unité de Formation et de Recherche en Sciences de la Santé (UFR-SDS), Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso | ||
| Abstract | ||
| Background: Many rapid antigen kits for SARS-CoV-2 detection have been developed and the results interpreted usually within 30 minutes. Antigen tests are recommended to be used in areas where access to the PCR method is limited, as is the case in Burkina Faso. The aim of this study is to assess the performance of "Standard TM Q COVID-19 Ag Test " in the detection of SARS-CoV-2 antigen. Methods: The evaluation was performed using swabs samples collected between January 26 and March 31, 2021, from 201 subjects previously diagnosed by RT-PCR. The performance of the rapid test “Standard TM Q COVID-19 Ag Test was compared to the RT-PCR test “STANDARD M nCoV real-time detection kit”. Results: Of these 201 samples, 16 were positive for the COVID-19 RT-PCR, and 185 were negative. The sensitivity of the "Standard TM Q COVID-19 Ag Test" was 100% (IC95%: 34.24- 100) in symptomatic subjects with a symptom onset time of 1 to 5 days. This sensitivity decreased to 66.67% (IC95%: 20.77- 93.85) in symptomatic subjects with a symptom onset time of 1 to 7 days. The specificity, it was 95% (IC95%: 83.5-98.62) in all symptomatic subjects and 93.75% (IC95%: 79.85-98.2) in subjects whose symptoms appeared between 1 and 5 days. Conclusion: The " Standard TM Q COVID-19 Ag Test " was better in subjects with delayed symptoms up to 5 days. However, this kit was not suitable for COVID-19 detection in asymptomatic subjects. | ||
| Keywords | ||
| COVID-19; SARS-CoV-2; Diagnosis; Antigen test; Burkina Faso | ||
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