TAURINE AMELIORATED THE COLONIC INFLAMMATORY SIDE EFFECTS OF INDOMETHACIN-TREATED RATS | ||
| Journal of the Egyptian Society of Parasitology | ||
| Volume 53, Issue 1, April 2023, Pages 1-8 PDF (1.09 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2023.297338 | ||
| Authors | ||
| AYA L. A. ALLAM; ALIAA M. ISSA; WAJEET N. SAYED | ||
| Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt | ||
| Abstract | ||
| Indometacin®, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammations. Common side effects are headache, nausea, upset stomach and dizziness; others were diarrhea, constipation, sleepiness, stomach pain & ear ringing (tinnitus). Also, with indomethacin the gastrointestinal tract's mucosa is adversely affected. Taurine is the most abundant semi-essential β-amino acid in mammals with a broad anti-inflammatory and antioxidant activity, approved by FDA with its relatively high daily safe dose as an on-shell supplement and in various clinical cases. The present study evaluated the effect of taurine on colonic inflammation and disrupted colonic architecture resulted as side effect in rats treated with indomethacin®. A total of seventy female Sprague-Dawley (SD( rats were divided into four groups: Control (W), Water and taurine (W+T), indomethacin-treated (INDO) and taurine-treated (T). In indomethacintreated group, rats received 1.5mg /1ml of water/rat for five consecutive days via intra-gastric gavage. In taurine-treated group, rats received taurine (0.05g/kg/day) in drinking water for one month after indomethacin treatment. Colonic inflammation, edema, macroscopic and microscopic damage were evaluated. The results showed that indomethacin drug given for five consecutive days caused severe colitis with high levels of occult blood and loose stool consistency. Severe colonic shrinkage and colonic edema were also observed. Histological examination revealed disrupted histological architecture with presence of cryptic distortion and abscesses. Ulceration was also observed with disruption of epithelial surface. After taurine treatment, the average rate of water consumption was increased. Stool consistency, occult blood and body weight change significantly improved. The rate of colon shrinkage and colonic edema were also reduced. Also, taurine treatment restored almost normal histological structure. | ||
| Keywords | ||
| Indomethacin; Taurine; colonic inflammation; colitis | ||
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