Isoniazid, Mechanism of action, Biological Activity, Resistance and Biotransformation | ||
| Journal of Advanced Medical and Pharmaceutical Research | ||
| Volume 4, Issue 2, September 2023, Pages 42-46 PDF (332.6 K) | ||
| Document Type: Short Communication | ||
| DOI: 10.21608/jampr.2023.202321.1052 | ||
| Authors | ||
| Ebtisam Taha Badawy* 1; Kamelia A. abouelsaoud2; Amal Kabbash3; Amany Ragab3 | ||
| 1Faculty of Pharmacy, Tanta university | ||
| 2Pharmacognosy department, Faculty of Pharmacy, Tanta university | ||
| 3Faculty of Pharmacy, Tanta University | ||
| Abstract | ||
| Isoniazid is a synthetic antimicrobial and one of the most essential first-line drugs used in the treatment of tuberculosis. In addition, isoniazid has been used as a prophylactic drug for patients with latent Mycobacterium tuberculosis infection to prevent reactivation of disease. It is a prodrug which activated by catalase peroxidase (KatG) enzyme. Catalase peroxidase enzyme converts isoniazid to reactive species. Isoniazid reactive species inhibit enoyl acyl-carrier protein reductase (InhA) enzyme which involved in the biosynthesis of fatty acids of mycobacteria. Isoniazid is metabolized by amidase enzyme into isonicotinic acid and hydrazine. Chronic toxicity of isoniazid results in hepatotoxicity and peripheral neuropathy. For active tuberculosis, isoniazid is often used together with rifampicin, pyrazinamide and either streptomycin or ethambutol. Multiple, extensively and totally drug resistant strains of Mycobacterium tuberculosis were reported. Due to the development of Mycobacterium tuberculosis resistance to isoniazid, a continuous search for new drugs is a demand to combat this global problem. | ||
| Keywords | ||
| Biological Activity; Isoniazid; Microbial Transformation; Resistance; Toxicity | ||
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