Correlation between Degree of Asthma Severity and Malondialdehyde in Asthmatic Children in Ismailia | ||
| Suez Canal University Medical Journal | ||
| Article 3, Volume 26, Issue 2, February 2023, Pages 17-24 PDF (342.82 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2023.299510 | ||
| Authors | ||
| Marwa A. Mohamed1; Alaa El-Din A. Zeitoun1; Fadia M. Attia2; Nouran B. AbdAllah* 1 | ||
| 1Pediatric Department, Faculty of Medicine, Suez Canal University, Egypt | ||
| 2Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| Background: Oxidative damage of several biomolecules is strongly involved in the pathogenesis of asthmatic inflammation. It is affecting airway functions causing an increase in the frequency of asthma attacks and deterioration. Aim: To determine Malondialdehyde level in both asthmatic children and the control group and to correlate its level to the degree of asthma severity.Subjects and Methods: Malondialdehyde (MDA) was measured in a group of Egyptian asthmatic children (55) and their matching controls (55) with an age range from 5 to 15 years who were attending the outpatient clinic in Suez Canal university hospital. Results: MDA level mean was higher in the studied asthmatic children than the control group being 3.32 ± 2.09 nmol/ml and 1.27 ± 0.20 nmol/ml respectively with a statistically significant difference. MDA level mean was found to correlate significantly and proportionally to the degree of asthma severity being 2.05 ±1.21 nmol/ml in intermittent asthma, 2.75 ± 1.75 nmol/ml in mild persistent, and 4.66 ± 2.12 nmol/ml in moderate persistent (p value<0.001). Conclusion:The findings of our study further strengthen the evidence that the altered oxidant-antioxidant balance is associated with airway obstruction. | ||
| Keywords | ||
| Asthma; oxidative stress; antioxidant status; free radicals; ROS | ||
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