Effects of Marbofloxacin and Ketoprofen on Some Biochemical and Coagulation Parameters in Calves | ||
| Journal of Applied Veterinary Sciences | ||
| Article 3, Volume 8, Issue 3, July 2023, Pages 16-21 PDF (489.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/javs.2023.208022.1225 | ||
| Authors | ||
| Mehmet Nihat URAL* 1; Kamil ÜNEY2 | ||
| 1Istanbul Directorate of Provincial Agriculture and Forestry, Kadıköy, Istanbul, Turkey | ||
| 2Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42031 Konya, Turkey | ||
| Abstract | ||
| Marbofloxacin (MBX) is a 3rd generation fluoroquinolone specifically developed for animal health and is an approved antimicrobial agent for the cure of mastitis and respiratory diseases in cattle and swine. Ketoprofen (KTP) is a nonsteroidal anti-inflammatory drugs (NSAID) belonging to the aryl propionic acid group and is used in musculoskeletal inflammation and pain, abdominal pain and other inflammatory circumstances. The objective of this study is to investigate the impact of simultaneous administration of MBX and KTP on the coagulation and biochemical parameters in calves. In the study, 18 clinically healthy calves were randomly separated into 3 groups of six animals each. The first group of calves received a single dose of MBX at 8 mg/kg, the second group received MBX at 8 mg/kg along with concurrent KTP at 3 mg/kg and the third group received only KTP at 3 mg/kg dose. The drugs were administered via intramuscular (IM) injection in the neck region. Biochemical and coagulation parameters were evaluated using an automated analyzer and coagulation analyzer, respectively. The IM injection of MBX into calves significantly increased creatine kinase (CK) and lactate dehydrogenase (LDH) values, which may be related to muscle damage. This may limit the administration via IM route of MBX to calves. KTP increased the prothrombin time (PT) and activated partial thromboplastin time (aPTT) values but decreased the fibrinogen value. It can be stated that in alone MBX, and KTP administration and their combination, further investigations are required to determine the safety of drugs after repeated administrations and other administration routes in calves. | ||
| Keywords | ||
| Biochemistry; Calve; Coagulation; Ketoprofen; Marbofloxacin | ||
| References | ||
|
ALLEN, S. 2009. The Association of Celecoxib, Rofecoxib, and Non-selective NSAIDs with Indices of Thrombosis and Endothelial Function in the Multi-Ethnic Study of Atherosclerosis [Doctoral dissertation]. Wake Forest University; 33 p.
COȘKUN, D., DIK, B., KORKMAZ, Y., CANBAR, R., and ER, A., 2019. Investigation of cardiotoxic effects of marbofloxacin. Eurasian J Vet Sci., 35(2):56-61. DOI: https://doi.org/10.15312/EurasianJVetSci.2019.223
DELEFORGE, J., THOMAS, E., DAVOT, J.L., and BOISRAME, B., 1994. A field evaluation of the efficacy of tolfenamic acid and oxytetracycline in the treatment of bovine respiratory disease. J Vet Pharmacol Ther., 17(1):43-47. DOI: https://doi.org/10.1111/j.1365-2885.1994.tb00520.x
EL-SAYED, M., EL-TAYSH, R., and EL-RAHMAN, A., 2019. Pharmacological Studies on Marbofloxacin on Diarrheic Calves. Mansoura Vet Med J., 20(1):6-13. DOI: https://doi.org/10.21608/MVMJ.2019.01.106
EMA., 1999. Committee for Veterinary Medicinal Products. Marbofloxacin Summary Report (2). Available online at: https://www.ema.europa.eu/en/documents/mrl-report/marbofloxacin-summary-report-2-committee-veterinary-medicinal-products_en.pdf (accesed: 01 Apr 2023). ER, A., DIK, B., CORUM, O., and CETIN, G., 2013. Cardiac safety of diclofenac at a single dose in ram. Sci World J., DOI: https://doi.org/10.1155/2013/808731
FERNÁNDEZ-VARÓN, E., GARCÍA-ROMERO, E., SERRANO-RODRÍGUEZ, J.M., CÁRCELES, C.M., GARCÍA-GALÁN, A., CÁRCELES-GARCÍA, C., FERNANDEZ, R., MUNOZ, C., and DE LA FE, C., 2021. PK/PD Analysis of Marbofloxacin by Monte Carlo Simulation against Mycoplasma agalactiae in Plasma and Milk of Lactating Goats after IV, SC and SC-Long Acting Formulations Administration. Animals., 11(4):1104. DOI: https://doi.org/10.3390/ani11041104 FRİTON, G., CAJAL, C., and RAMİREZ-ROMERO, R., 2005. Long-term effects of meloxicam in the treatment of respiratory disease in fattening cattle. Vet Rec., 156, 25, 809-11. DOI:https://doi.org/10.1136/vr.156.25.809
GRANDEMANGE, E., PERRIN, P.A., CVEJIC, D., HAAS, M., ROWAN, T., and HELLMANN, K., 2017. Randomised controlled field study to evaluate the efficacy and clinical safety of a single 8 mg/kg injectable dose of marbofloxacin compared with one or two doses of 7.5 mg/kg injectable enrofloxacin for the treatment of Actinobacillus pleuropneumoniae infections in growing-fattening pigs in Europe. Porc Health Manag., 3:1-12. DOI: https://doi.org/10.1186%2Fs40813-017-0057-2 GUNAYDIN, C., and BILGE, S.S., 2018. Effects of nonsteroidal anti-inflammatory drugs at the molecular level. The Eurasian journal of medicine., 50(2):116. DOI: https://doi.org/10.5152/eurasianjmed.2018.0010
JAGER, N.G., VAN, HEST R.M., LIPMAN, J., TACCONE, F.S., and ROBERTS, J.A., 2016. Therapeutic drug monitoring of anti-infective agents in critically ill patients. Expert Rev Clin Pharmacol., 1-19. https://doi.org/10.1586/17512433.2016.1172209
LASCELLES, B.D.X., MCFARLAND, J.M., and SWANN, H., 2005. Guidelines for safe and effective use of NSAIDs in dogs. Vet Ther., 6(3):237.
LEI Z LIU, Q., YANG, B., KHALIQ, H., CAO, J., and HE Q., 2017. PK-PD analysis of marbofloxacin against Streptococcus suis in pigs. Front Pharmacol., 8:856. DOI: https://doi.org/10.3389/fphar.2017.00856 LIU, X., MA, J., HUANG, L., ZHU, W., YUAN, P., WAN, R., and HONG, K., 2017. Fluoroquinolones increase the risk of serious arrhythmias: a systematic review and meta-analysis. Medicine., 96(44). DOI: https://doi.org/10.1097/MD.0000000000008273
MANT, T., MORRISON, P., and MILLAR, E., 1992. Absence of drug interaction between temafloxacin and low dose heparin. Clin Pharmacokinet. 22:98-101. https://doi.org/10.2165/00003088-199200221-00016.
MARTÍNEZ, M., MCDEMOTT, P., and WALKER, R., 2006. Pharmacology of the fluorquinolones: A perpective for the use in domestic animals. Vet J., 172:10–28. https://doi.org/10.1016/j.tvjl.2005.07.010 PAPICH, M.G. 2021. Ketoprofen. In: Papich Handbook of Veterinary Drugs Fifth Ed. St. Louis:Saunders Elsevier; 498-500 p.
PATIL, N.A., SATBIGE, A.S., AWATI, B., and HALMANDGE, S., 2021. Therapeutic management of subclinical mastitis in buffaloes. Buffalo Bull., 40(1):157-160. ROBERTS, J.A., NORRIS, R., PATERSON, D.L., and MARTIN, J.H., 2012. Therapeutic drug monitoring of antimicrobials. Br J Clin Pharmacol., 73(1):27-36. DOI: https://doi.org/10.1111/j.1365-2125.2011.04080.x
RUSU, A., MUNTEANU, A.C., ARBĂNAȘI, E.M., and UIVAROSI, V., 2023. Overview of Side-Effects of Antibacterial Fluoroquinolones: New Drugs versus Old Drugs, a Step Forward in the Safety Profile?. Pharmaceutics., 15(3):804. DOI: https://doi.org/10.3390/pharmaceutics15030804
SIDHU, P.K., LANDONI, M.F., ALIABADI, F.S., and LEES, P., 2010. PK–PD integration and modeling of marbofloxacin in sheep. Res Vet Sci., 88(1):134-141. DOI: https://doi.org/10.1016/j.rvsc.2009.05.013 SINGH, R.D., DEVI, S., GONDALIYA, S.R., BHAVSAR, S.K., and THAKER, A.M., 2009. Safety of Ketoprofen in Cow calves following repeated intravenous administration. Vet World., 2(3):105.
SRIUTTHA, P., SIRICHANCHUEN, B., and PERMSUWAN, U., 2018. Hepatotoxicity of nonsteroidal anti-inflammatory drugs: a systematic review of randomized controlled trials. Int J Hepatol. DOI: https://doi.org/10.1155/2018/5253623
STICHTENOTH, D.O., TSIKAS, D., GUTZKI, F.M., and FRÖLICH, J.C., 1996. Effects of ketoprofen and ibuprofen on platelet aggregation and prostanoid formation in man. Eur J Clin Pharmacol., 51:231-234.
THOMAS, M.V., and PULEO, D., 2011. Infection, inflammation, and bone regeneration: a paradoxical relationship. J Dent Res., 90(9):1052-1061. DOI: https://doi.org/10.1177/0022034510393967
TRIPODI, A., CHANTARANGKUL, V., and MANNUCCI, P.M., 2009. Acquired coagulation disorders: revisited using global coagulation/anticoagulation testing. Br J Haematol., 147(1): 77-82. DOI: https://doi.org/10.1111/j.1365-2141.2009.07833.x
ZANUZZO, F.S., TEIXEIRA‐NETO, F.J., THOMAZINI, C.M., TAKAHIRA, R.K., CONNER, B., and MIRIELY, S., 2015. Effects of dipyrone, meloxicam, or the combination on hemostasis in conscious dogs. J Vet Emerg Crit Care., 25(4):512-520. DOI: https://doi.org/10.1111/vec.12336
ZIEMEN, M., BREDDIN, K., and SHAH, P.M., 1998. Haemostasis during treatment with ciprofloxacin. Infection., 16:65 https://doi.org/10.1007/BF01650512
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