INVESTIGATION OF THE PREVALENCE OF CANDIDURIA IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES IN HOMS – SYRIA | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Volume 46, Issue 1, June 2023, Pages 465-472 PDF (689.87 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2023.301182 | ||
| Authors | ||
| Rafah Alali* 1; Walid Khaddam1; Sundus Yaseen2 | ||
| 1Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al-Baath University, Homs, Syria | ||
| 2Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al-Kalamoon University, Deratiah, Syria | ||
| Abstract | ||
| The aim of this study was to investigate the incidence of candiduria in patients with hematologic malignancies, and identity its causative agents. The study included 100 patients with one of the following diseases: Acute myeloid leukemia (AML), Chronic myeloid leukemia (CML), Acute lymphoid leukemia (ALL), Chronic lymphoid leukemia (CLL), Multiple myeloma (MM), Hodgkin's lymphoma (HL) and Non-Hodgkin's lymphoma (NHL), who were admitted to the Hematology Department in some hospitals in Homs-Syria between December 2020 to September 2021. Candida species were identified by colony color on CHROMagar candida, germ tube production and micro-morphology on cornmeal agar. Among the 100 patients, 13 (13%) were positive for candiduria. C. albicans was the most common cause of candiduria (61.5%), followed by C. tropicalis and C. krusei (15.4%, respectively) and C. dubliniensis (7.7%). According to the results of the statistical analysis, candiduria was found to correlate significantly with female gender, previous exposure to a urinary catheter, acute myeloid leukemia (AML) and severe neutropenia (<500 cells/mm3). | ||
| Keywords | ||
| Candiduria; Fungal infections; Hematologic malignancies; Opportunistic infections | ||
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