Epithelial-Mesenchymal Transition Axis Lin 28, ARID1A, And ELF3 As A Novel Prognostic Triad in Invasive Ductal Breast Carcinoma | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 196, Volume 91, Issue 1, April 2023, Pages 5018-5029 PDF (1.08 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2023.301785 | ||
| Authors | ||
| Sabah Mohamed Hanafy; Eman Elsayed Fayad; Mohamed Ali Alabiad* | ||
| Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||
| Abstract | ||
| Background: Breast cancer is the most often identified cancer in women and considered the second principal cause of cancer death among all women. Objective: The aim of the study was to evaluate the relationship between Epithelial-mesenchymal Transition markers Lin 28, ARID1A, and ELF3 and the clinicopathological parameters and outcomes in invasive ductal breast carcinoma. Materials and Methods: This retrospective study was on 120 breast cancer cases by evaluation the immunohistochemical expression of Lin 28, ARID1A, and ELF3 and correlation their expression with the clinicopathological and the outcome parameters of the patients. Results: Lin 28, ARID1A and ELF3 expression statistically significant correlation with tumor size, with a high KI67 index, positive ER/ PR expression and Her-2/neu, high grade lymph node metastasis, lymph vascular invasion, perineural invasion and mortality. Conclusions: Overexpression of the mesenchymal stem cell markers (ARID1A-1 and Lin23) and a decrease in the expression of the epithelial markers (ELF3) were strongly related poor prognostic and clinicopathological parameters of invasive ductal breast cancer. | ||
| Keywords | ||
| Lin 28; ARID1A; ELF3; Invasive ductal breast carcinoma | ||
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