Abakpa, S., J. Fambegbe, T., B. Oluwayinka, E., O. Egbetade, A., A. Raman, S., R. Idowu, K., F. Okpe, E. (2023). Assessment of Serum Proinflammatory Cytokines and Some Associated Haematobiochemical Indices in An experimental Canine Trypanosomiasis. test, 54(5), 815-823. doi: 10.21608/ejvs.2023.199184.1460
Simon Abah Victor Abakpa; Temiloluwa J. Fambegbe; Eniope B. Oluwayinka; Adeniyi O. Egbetade; Samson A. Raman; Kemi R. Idowu; Edwin F. Okpe. "Assessment of Serum Proinflammatory Cytokines and Some Associated Haematobiochemical Indices in An experimental Canine Trypanosomiasis". test, 54, 5, 2023, 815-823. doi: 10.21608/ejvs.2023.199184.1460
Abakpa, S., J. Fambegbe, T., B. Oluwayinka, E., O. Egbetade, A., A. Raman, S., R. Idowu, K., F. Okpe, E. (2023). 'Assessment of Serum Proinflammatory Cytokines and Some Associated Haematobiochemical Indices in An experimental Canine Trypanosomiasis', test, 54(5), pp. 815-823. doi: 10.21608/ejvs.2023.199184.1460
Abakpa, S., J. Fambegbe, T., B. Oluwayinka, E., O. Egbetade, A., A. Raman, S., R. Idowu, K., F. Okpe, E. Assessment of Serum Proinflammatory Cytokines and Some Associated Haematobiochemical Indices in An experimental Canine Trypanosomiasis. test, 2023; 54(5): 815-823. doi: 10.21608/ejvs.2023.199184.1460

Assessment of Serum Proinflammatory Cytokines and Some Associated Haematobiochemical Indices in An experimental Canine Trypanosomiasis

Egyptian Journal of Veterinary Sciences
Volume 54, Issue 5, September and October 2023, Pages 815-823    PDF (1.3 M)
Document Type: Original Article
DOI: 10.21608/ejvs.2023.199184.1460
Authors
Simon Abah Victor Abakpa* 1; Temiloluwa J. Fambegbe2; Eniope B. Oluwayinka3; Adeniyi O. Egbetade3; Samson A. Raman4; Kemi R. Idowu5; Edwin F. Okpe3
1Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
2Department of Veterinary Medicine, , Nigeria
3Department of Veterinary Medicine, Nigeria
4Department of Veterinary Physiology and Biochemistry, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria
5Veterinary Teaching hospital, Federal University of Agriculture, Abeokuta, Nigeria
Abstract
THIS research assessed the concentrations of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukin-6 (IL-6) in Nigerian indigenous dogs (NID) experimentally infected with Trypanosoma congolense (T. congolense) and correlated with some haematological and biochemical indices.  Fifteen NID of weight (9.3±1.04 kg) were randomly assigned into three groups of five each. Group A was uninfected and untreated. Group B received T. congolense (2.5 x 105), but untreated. Group C received T. congolense (2.5 x 105) and treated with diminazene aceturate on day 17 post-infection (pi). Blood was obtained pre-infection, pi and post-treatment (pt) for cytokines assessment using ELISA. Serum TNF-α increased significantly (p < 0.05) in groups B and C on days 10 and 17 pi but decreased on day 5 pt in group C compared to groups A and B.  Serum IL-6 increased significantly in groups B and C on days 1 to 22 pi. Both TNF-α and IL-6 correlated positively with monocytes count, creatinine, and urea.  Serum TNF-α correlated negatively with PCV, erythrocytes count, haemoglobin concentration (Hb) and albumin, while IL-6 correlated negatively with on PCV, Hb and albumin. In conclusion, IL-6 was elevated post infection and remained elevated post treatment. Tumour necrosis factor - alpha concentration was elevated in NID infected with T. congolense, but decreased significantly post treatment. Both IL-6 and TNF-α positively or negatively associated with assessed haematological and biochemical indices. In conclusion, proinflammatory cytokines are elevated in NID experimentally infected with T. congolense and caused some pathology.
Keywords
Proinflammatory cytokines; diminazene aceturate; dogs; T. congolense
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