El awady, M., Hamed, A., El abacy, D., Battah, M., Hassan, M. (2023). Bioactive secondary metabolite from marine Streptomyces parvulus strain MDA with potential antibacterial activity. test, 66(13), 2331-2341. doi: 10.21608/ejchem.2023.205001.7842
Mohamed E. El awady; Ahmed A. Hamed; Donia G. El abacy; Mohamed G. Battah; Mervat G. Hassan. "Bioactive secondary metabolite from marine Streptomyces parvulus strain MDA with potential antibacterial activity". test, 66, 13, 2023, 2331-2341. doi: 10.21608/ejchem.2023.205001.7842
El awady, M., Hamed, A., El abacy, D., Battah, M., Hassan, M. (2023). 'Bioactive secondary metabolite from marine Streptomyces parvulus strain MDA with potential antibacterial activity', test, 66(13), pp. 2331-2341. doi: 10.21608/ejchem.2023.205001.7842
El awady, M., Hamed, A., El abacy, D., Battah, M., Hassan, M. Bioactive secondary metabolite from marine Streptomyces parvulus strain MDA with potential antibacterial activity. test, 2023; 66(13): 2331-2341. doi: 10.21608/ejchem.2023.205001.7842

Bioactive secondary metabolite from marine Streptomyces parvulus strain MDA with potential antibacterial activity

Egyptian Journal of Chemistry
Volume 66, Issue 13, December 2023, Pages 2331-2341    PDF (1.19 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.205001.7842
Authors
Mohamed E. El awady* 1; Ahmed A. Hamed2; Donia G. El abacy3; Mohamed G. Battah3; Mervat G. Hassan4
1Microbial Biotechnology Department, National Research Centre, National Research Centre, 33 El-Buhouth Street, P.O. Box 12622, Dokki, Giza, Egypt
2National research center, Cairo Microbial Chemistry department, National Research Centre, 33 El-Buhouth Street,
3Botany and Microbiology Department, Faculty of Science, Benha Univ., Benha, Egypt.
4Botany and Microbiology Dept., Faculty of Science, Banha University, Egypt.
Abstract
The finding as well as the subsequent medical history of antimicrobials has become one of the most significant game modifications in medical history. As a result, a natural substance of 2-Methyl butyl propyl phthalate was extracted from a marine-derived Streptomyces parvulus strain MDA remoted originating along the Red Sea coast; Hurghada. The elimination of Streptomyces parvulus strain MDA via 2-Methyl butyl propyl phthalate became an exciting topic in our study; locating was tested using a minimal bactericidal concentration (MBC) of 300 µg/ml and an 80 µg/ml minimum inhibitory concentration (MIC). The kinetic time killer graph illustrated that the microorganisms damaged cells in 5 hours. The fractionation and purification of 2-Methyl butyl propyl phthalate were completed by the use of silica gel column G254, thin layer chromatography (TLC), liquid chromatography (LC), and nuclear magnetic resonance (NMR), which helped in the elucidation of the structure of 2-Methyl butyl propyl phthalate with the molecular components of C16H22O4.
Keywords
Streptomyces parvulus; Bioactive metabolite; Antibacterial; 2-Methyl butyl propyl phthalate
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