Immunohistochemical Expression of Vascular Endothelial Growth Factor (VEGF) in Colorectal Carcinoma | ||
| Suez Canal University Medical Journal | ||
| Article 5, Volume 26, Issue 3, March 2023, Pages 0-0 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2023.304984 | ||
| Author | ||
| Omnia Ezzat | ||
| Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
| Abstract | ||
| Background: VEGF-A and its receptors VEGFR-1 and VEGFR-2 play major roles in physiological and pathological angiogenesis, including tumor angiogenesis. VEGF-A is produced by diverse cell types, including aortic vascular smooth muscle cells, keratinocytes, macrophages, and many tumor cells. Aim:The aim of our work was to assess the expression of VEGF protein in colorectal carcinoma and to study the association between VEGF expression, clinical and histopathological parameters. Materials and Methods:fifty-two specimens of colorectal carcinoma were stained immunohistochemically with VEGF polyclonal antibody and scored by two histopathologists. Results: fifty-two specimens showed positive cytoplasmic expression of VEGF; with variable degrees. VEGF expression showed no statistically significant association between its expression and the patients’ demographic data, perineural invasion, or lymphovascular invasion. VEGF protein expression increases with an increase in the grade and stage of colorectal carcinoma. Conclusion: VEGF protein expression increases with an increase in the grade and stage of colorectal carcinoma. VEGF expression showed no statistically significant relationship with patient age, sex, peri-neural invasion, or lymphovascular invasion. It could also improve patient outcomes when specifically targeted with appropriate pharmacological agents; a promising domain that still requires more research. | ||
| Keywords | ||
| VEGF; immunohistochemistry; colorectal carcinoma | ||
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