Prognostic value of complement 4 in covid-19 pediatric patients | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 04 July 2023 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2023.217079.1417 | ||
| Authors | ||
| Ahmed Mohsen Anwar* 1; Samir Tamer Abdullah2; Reem Abdel-Salam Abd el- Azeez3; Hend mohamed moaness4 | ||
| 1Department of pediatrics; faculty of medicine; minia university | ||
| 2Pediatrics, faculty of medicine, minia university, Egypt | ||
| 3pediatrics, faculty of medicine Minia University, Egypt | ||
| 4Clinical pathology department,faculty of medicine ,minia university, Egypt | ||
| Abstract | ||
| Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused pandemic of COVID-19, which has killed 2 million people worldwide and infected over 97 million more, is now the most catastrophic public health disaster in a century. Objectives: to assess the prognostic value of complement 4 with disease severity in covid-19 pediatric patients. Patients and methods: our patients were selected from Pediatrics inpatient department and outpatient pediatric clinic, faculty of medicine, Minia University. It was conducted during the period March 2021 till June 2021. One hundred and fifty patients were included in our study. Result: Out of 300 children were diagnosed as Covid-19, One hundred and fifty patients were included in our study according to the inclusion criteria divided into four groups (mild, moderate, severe and critical). C4 was significantly lower in both severe and critical groups than the other 2 groups (mild &moderate). Conclusion: Complement 4, indicating excessive complement activation and product consumption is significantly associated with presence of severe disease and increased mortality in patients with COVID-19. So, complement 4 can be a prognostic factor for mortality in covid -19 pediatric patients. Keywords: COVID-19, pediatric patients, Complement 4, Prognostic value and severity. | ||
| Keywords | ||
| Children; immune; predictor; severity | ||
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