PROPHYLACTIC EFFECT OF NIGELLA SATIVA L. POWDER AGAINST OXIDATIVE STRESS INDUCED BY CYPERMETHRIN IN BROILERS | ||
| Journal of the Egyptian Veterinary Medical Association | ||
| Volume 79, Issue 1, March 2019, Pages 169-188 PDF (666.37 K) | ||
| Document Type: Original Research Articles | ||
| Abstract | ||
| Unsexed 60 Lohmann broiler chicken of 1-day-old were weighed and reared up to 2 weeks and allotted to 4 dietary treatment groups each of 15 birds. The first group received normal broiler fattening feed free of any additive and served as control. The 2nd group was fed on 10 g/kg diet nigella sativa powder (NS) whereas, the 3rd group was fed on 600 mg/kg diet cypermethrin and 4th group was fed on 10 g/kg diet NS and 600 mg/kg diet cypermethrin (CYP), for a month up to 44 - days old. NS induced a significant improvement in live body weight (LBW), body weight gain (BWG), feed intake (FI) and performance index (PI) and feed conversion ratio (FCR) in CYP intoxicated broilers. CYP residue levels in peritoneal fat, breast, thigh muscles, liver and kidney were below the maximum residue level (MRL). Dietary NS induced a significant reduction in CYP residues in peritoneal fat, and thigh muscles, liver and accumulation of CYP residues were the highest in liver followed by peritoneal fat, thigh, breast and kidney. CYP induced a significant increase in serum ALT, AST, ALP, urea, creatinine, hepatic lipid peroxide, malondialdehyde (MDA) levels as well as hepatocellular DNA damage (% DNA in tail, tail length and the olive tail moment (OTM)), while evoked a significant decrease in the activities of hepatic catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GHS px) and superoxide dismutase (SOD). However, NS powder significantly ameliorated oxidative stress, biochemical disorders and geno-toxicity produced by cypermethrin. | ||
| Keywords | ||
| Cypermethrin; Nigella sativa; Growth Performance; oxidative stress; DNA; broilers | ||
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