Serum Chemerin as a Marker for Early Detection of Metabolic Syndrome in Obese Children | ||
| Suez Canal University Medical Journal | ||
| Article 9, Volume 26, Issue 5, May 2023, Pages 0-0 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2023.306940 | ||
| Authors | ||
| Ahmed A. Ali* 1; Amina M. Abdel Wahab2; Suzan S. Gad2; Sanaa S. Nassar2 | ||
| 1Department of Pediatrics, El Ibrahimiya central hospital, Sharqia, Egypt | ||
| 2Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| Background: Chronic inflammatory conditions include metabolic syndrome (MetS), one of the most important worldwide health concerns. Chemerin, an adipokine, is involved in the relationship between MetS and inflammation. Aim: The goal of our research was to assess if serum chemerin might be used as a marker for early diagnosis of metabolic syndrome. Methods: The study included 42 obese and 42 non-obese healthy children and adolescents ranging in age from 5 to 17 years old. The subjects' anthropometric and blood pressure measurements were taken. The following data were collected: fasting blood glucose, serum triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c). The level of chemerin was measured using ELISA. Results: Serum chemerin levels were substantially greater in MetS obese than in non-MetS obese and healthy subjects (1211.71569 ng/ml versus 337.534.8 ng/ml and 470.3475.8 ng/ml, respectively, p0.001). By using correlation and multiple linear regression analysis, serum chemerin levels were found to be significantly correlated to impaired fasting blood sugar (r= 0.398, p = 0.009) and poor HDL (r= -0.386, p = 0.012). Conclusion: Chemerin levels in the blood have been linked to metabolic syndrome and could be used as an independent diagnostic marker for the condition. | ||
| Keywords | ||
| Children; metabolic syndrome; chemerin; obesity | ||
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