Ali, O., Fouda, E., Abdelhamid, D., Sherif, B. (2023). SCREENING FOR LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN WITH CYSTIC FIBROSIS. test, 74(2), 405-412. doi: 10.21608/asmj.2023.307104
Omnia Hendawy Radwan Ali; Eman Mahmoud Fouda; Dalia Hosni Abdelhamid; Basma Sherif. "SCREENING FOR LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN WITH CYSTIC FIBROSIS". test, 74, 2, 2023, 405-412. doi: 10.21608/asmj.2023.307104
Ali, O., Fouda, E., Abdelhamid, D., Sherif, B. (2023). 'SCREENING FOR LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN WITH CYSTIC FIBROSIS', test, 74(2), pp. 405-412. doi: 10.21608/asmj.2023.307104
Ali, O., Fouda, E., Abdelhamid, D., Sherif, B. SCREENING FOR LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN WITH CYSTIC FIBROSIS. test, 2023; 74(2): 405-412. doi: 10.21608/asmj.2023.307104

SCREENING FOR LOWER RESPIRATORY TRACT INFECTIONS IN CHILDREN WITH CYSTIC FIBROSIS

Ain Shams Medical Journal
Volume 74, Issue 2, June 2023, Pages 405-412    PDF (239.75 K)
Document Type: Original Article
DOI: 10.21608/asmj.2023.307104
Authors
Omnia Hendawy Radwan Ali1; Eman Mahmoud Fouda2; Dalia Hosni Abdelhamid1; Basma Sherif* 3
1Clinical Pathology, Faculty of Medicine Ain Shams University Hospitals, Cairo, Egypt.
2Paediatric departments, Faculty of Medicine Ain Shams University Hospitals, Cairo, Egypt.
3Clinical Pathology department, Faculty of Medicine, Ain Shams University Hospitals, Cairo, Egypt
Abstract
Background: Cystic fibrosis (CF) is a chronic autosomal recessive disease caused by CF transmembrane conductance regulator (CFTR) gene mutations, which encodes the CFTR protein. Impaired function of this protein leads to increased mucus thickness with subsequent chronic infections. The fungal biota in CF is dominated by Aspergillus and Candida species (spp). Aim of the Work: To determine the common lower respiratory tract infections among CF pediatric patients and to correlate culture results with the patient clinical status. Patients and Methods: A Cross Sectional Study was applied on 32 lower respiratory samples collected from CF pediatric patients admitted to Chest department, Pediatric Hospital, Ain Shams University. Samples were tested through bacterial and fungal culture. Results: Bacterial growth was detected in five samples (15.6%), where Pseudomonas spp was the most common bacteria, Fungal growth was detected in three samples (9.4%), all showed growth of Candida spp. Two samples showed mixed growth of Pseudomonas spp and Candida non albicans. Conclusion: Pseudomonas spp was the most frequent pathogen isolated from CF patients. Candida spp was the predominant fungal species detected.
Keywords
Cystic fibrosis; pediatrics; respiratory tract infections; fungal infections; Candida
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