(2018). CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE. test, 78(2), 301-308.
. "CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE". test, 78, 2, 2018, 301-308.
(2018). 'CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE', test, 78(2), pp. 301-308.
CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE. test, 2018; 78(2): 301-308.

CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE

Journal of the Egyptian Veterinary Medical Association
Volume 78, Issue 2, July 2018, Pages 301-308    PDF (369.22 K)
Document Type: Original Research Articles
Abstract
The current study was conducted to investigate the effect of unpredictable chronic mild stress as a model of depression on the physiological and neurochemical parameters of male swiss mice. Twenty- Five adult male Swiss albino mice were housed in either control group or unpredictable chronic mild stress (UCMS) group that was exposed to different physical
stressors for 8 weeks. Plasma corticosterone and brain stem levels of dopamine and serotonin (5-OH) were measured. UCMS mice displayed an increase in the plasma corticosterone concentration and lower levels of both brain stem dopamine and 5- OHT compared to controls. In conclusion, the presence of physiological changes along with the significant neurobiological changes in the brain strongly support the efficacy of UCMS as a model of depression in the human being.
Keywords
Depression; Swiss mice; Unpredictable chronic mild stress; corticosterone; dopamine; serotonin
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