Study of Vitamin D and Interleukin 10 Levels in Uremic Peripheral Neuropathy in Children on Hemodialysis. | ||
| GEGET | ||
| Article 2, Volume 18, Issue 1, June 2023, Pages 12-22 PDF (249.77 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/geget.2023.308019 | ||
| Authors | ||
| Faika Shehta Arab* 1; Nesma Abdelmoneam Ghonimi2; Aya Abdel-Moneam Elshahawy3; Mona Hamed Gehad1; Mayy Abd Alfattah Neemat-Allah1 | ||
| 1Department of Pediatrics, Faculty of Medicine, Zagazig University, Sharkia, Egypt. | ||
| 2Department of Neurology , Faculty of Medicine, Zagazig University, Sharkia, Egypt. | ||
| 3Department, of Clinical Pathology, Faculty of Medicine, Zagazig University, Sharkia, Egypt. | ||
| Abstract | ||
| Introduction: One of the frequent neurological complications of end stage kidney disease (ESKD) is uremic peripheral neuropathy (UPNP). A rapidly expanding literature on the relationship between 25(OH) vitamin D and UPNP shows a high link between them. Interleukin 10(IL-10) reduced level may contributes to UPNP. The aim was to assess the correlation between serum levels of vitamin D and IL-10 with the incidence of UPNP in children on regular hemodialysis. Methods: A cross-sectional study included 71 children on regular hemodialysis, aged between 3 and 18 years. They were sub classified into two groups after assessment with nerve conduction studies (NCS) and neuropathy score; group I consisted of 24 patients with PNP and group II consisted of 47 patients without PNP. All patients were subjected to clinical examination, laboratory investigations and serum 25(OH) vitamin D and IL-10. Results: Patients with PNP had significantly lower serum levels of IL-10 (P<0.001**) and 25(OH) vitamin D (P=0.003*) than those without PNP. 70% of patients with PNP had vitamin D deficiency with statistically significant difference (P < 0.001). The serum levels of 25(OH) vitamin D and IL-10 have a statistically significant negative correlation with severity of UPNP. There was a significant positive correlation between IL-10 and vitamin D levels (P= 0.022). Longer duration of dialysis with age more than 11 years, low vitamin D, and low IL-10 were independent variables for UPNP. Conclusions: Low vitamin D and IL-10 levels increase the risk of PNP in children on hemodialysis | ||
| Keywords | ||
| End stage kidney disease; Uremic peripheral neuropathy; Interleukin-10, Hemodialysis | ||
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