Said, A., Yassin, S., Mohammad, S., Muhammad, E., Abdelnaby, A., Ali, W. (2023). Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats. test, 41(2), 24-32. doi: 10.21608/ajfm.2023.308116
Ahmed Said; Sara Yassin; Soheir Mohammad; Eman Muhammad; Amira Abdelnaby; Wafaa Ali. "Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats". test, 41, 2, 2023, 24-32. doi: 10.21608/ajfm.2023.308116
Said, A., Yassin, S., Mohammad, S., Muhammad, E., Abdelnaby, A., Ali, W. (2023). 'Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats', test, 41(2), pp. 24-32. doi: 10.21608/ajfm.2023.308116
Said, A., Yassin, S., Mohammad, S., Muhammad, E., Abdelnaby, A., Ali, W. Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats. test, 2023; 41(2): 24-32. doi: 10.21608/ajfm.2023.308116

Studying the Protective Effect of N-acetyl cysteine and Lcarnitine on Testicular Toxicity Induced by Valproic Acid Administration in Adult Male Albino Rats

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Volume 41, Issue 2, July 2023, Pages 24-32    PDF (1.2 M)
Document Type: Original Article
DOI: 10.21608/ajfm.2023.308116
Authors
Ahmed Said1; Sara Yassin1; Soheir Mohammad1; Eman Muhammad2; Amira Abdelnaby2; Wafaa Ali1
1Forensic medicine and Clinical Toxicology, Sohag Faculty of medicine, Sohag University, Egypt.
2Pathology Department, Sohag Faculty of medicine, Sohag University, Egypt
Abstract
Introduction: Sodium valproate (VPA) is a well-known antiepileptic drug used in treatment of 
generalized seizures and cause many toxic effects. Aim: This study aimed to highlight the VPA 
effects on testes in adult male albino rats and protective effect of N- acetyl cysteine (NAC) and 
L-carnitine. Methodology: Sixty adult male albino rats divided into six groups randomly, 10 rats 
each, group I: negative control group not received any treatment. group II: positive control 
group received NAC 150 mg/kg/day orally, group III: positive control group received Lcarnitine 500 mg/kg/day orally, group IV: received VPA 400 mg/kg/day orally which equals 
40/67 of Ld50 of valproic acid in rats, group V: received VPA 400 mg/kg and NAC 150 mg/kg 
daily orally, group VI: received VPA 400 mg/kg and L-carnitine 500 mg/kg daily orally for 45 
days. Results: This study revealed high significant difference between group received VPA (IV) 
in form of marked decrease in serum testosterone compared to control groups (I, II, III), 
laboratory parameters are co-incident with histopathological findings in testes of these groups. 
We found a significant improvement in laboratory parameters in the form of higher serum 
testosterone levels in groups received antioxidants with VPA (V, VI), co-incident with 
histopathological findings in testes of these groups, with a higher protective power of Lcarnitine than N- acetyl cysteine. Conclusion: Sodium valproate induces testicular toxicity in 
high doses (400 mg/kg) in male albino rats. There is a protective role for both NAC and Lcarnitine. L-carnitine exhibited more protective effect than NAC on their administration with 
VPA.
Received in original form: 30 March 2023 Accepted in a final form: 24 May 2023
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