Fabrication of bioactive wound dressing containing carbopol, hyaluronic acid and Na-alginate | ||
| Egyptian Journal of Chemistry | ||
| Volume 67, Issue 1, January 2024, Pages 343-352 PDF (781.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.217051.8124 | ||
| Authors | ||
| H.M. Fahmy; Moustafa M.G. Fouda; A. Amr; A. Abou-Okeil* | ||
| Textile Research and Technology Institute, National Research Center, Cairo, Egypt. | ||
| Abstract | ||
| Novel wound dressings were prepared by treating non-woven cotton fabric samples with different formulations of carbopol (CP), hyaluronic acid (HA), and sodium alginate (HA) followed by crosslinking with Ca2+, Zn2+ or Cu2+ ions. The impacts of such formulations on the antibacterial besides, some physico-mechanical properties of such dressings were studied. Loading the crosslinked CP/HA/SA dressing with sodium diclofenac and its in-vitro releasing from that dressing at pH 7 was investigated. To improve the antibacterial activities of such dressing, silver nano-particles were incorporated as a bioactive agent in the dressing formulation. The CP/HA/SA crosslinked film was characterized via FTIR analysis whereas the CP/HA/SA dressing SEM and EDX images were investigated. | ||
| Keywords | ||
| Wound dressing; Carbopol; Hyaluronic acid; Sodium alginate; Metal ions | ||
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