Vitiligo: A Comprehensive Review | ||
| Benha Journal of Applied Sciences | ||
| Article 37, Volume 8, Issue 2, February 2023, Pages 93-99 PDF (458.48 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2023.214672.1180 | ||
| Authors | ||
| Adel Ebrahim1; Samah Ibrahiem1; Asmaa El-fallah2; Shereen Awad* 1 | ||
| 1Dermatology, Venereology and Andrology Dept., Faculty of medicine, Benha University | ||
| 2Clinical and Chemical Pathology Dept., Faculty of medicine, Benha University | ||
| Abstract | ||
| Background: Vitiligo is a common dermatological condition characterized by the presence of acquired, amelanotic, non-scaly, chalky-white macules with distinct margins on the skin. It is a multifactorial disorder involving the complex interplay of genetic, autoimmune, and environmental factors. Vitiligo can have a significant impact on the quality of life of affected individuals due to its visible nature and the associated psychosocial implications. Objectives: This review article aims to provide an overview of vitiligo, including its epidemiology, etiology, clinical features, and current understanding of the underlying mechanisms. The objectives are to explore the prevalence and distribution of vitiligo worldwide, discuss the potential causes and risk factors, and highlight the diverse clinical presentations observed in different subtypes of vitiligo. Conclusions: Vitiligo is a complex and heterogeneous disorder with a wide range of clinical manifestations. Although the exact etiology remains elusive, advancements in research have shed light on the involvement of immune dysregulation, oxidative stress, and genetic predisposition in the pathogenesis of vitiligo. Diagnosis of vitiligo is primarily clinical, based on characteristic depigmented macules, while further investigations may be warranted to exclude other conditions. Management of vitiligo involves a multidisciplinary approach, including topical therapies, phototherapy, surgical interventions, and psychological support. While repigmentation outcomes vary, advancements in targeted therapies and immunomodulatory agents hold promise for future treatment strategies. Background: Vitiligo is a common dermatological condition characterized by the presence of acquired, amelanotic, non-scaly, chalky-white macules with distinct margins on the skin. It is a multifactorial disorder involving the complex interplay of genetic, autoimmune, and environmental factors. Vitiligo can have a significant impact on the quality of life of affected individuals due to its visible nature and the associated psychosocial implications. Objectives: This review article aims to provide an overview of vitiligo, including its epidemiology, etiology, clinical features, and current understanding of the underlying mechanisms. The objectives are to explore the prevalence and distribution of vitiligo worldwide, discuss the potential causes and risk factors, and highlight the diverse clinical presentations observed in different subtypes of vitiligo. Conclusions: Vitiligo is a complex and heterogeneous disorder with a wide range of clinical manifestations. Although the exact etiology remains elusive, advancements in research have shed light on the involvement of immune dysregulation, oxidative stress, and genetic predisposition in the pathogenesis of vitiligo. Diagnosis of vitiligo is primarily clinical, based on characteristic depigmented macules, while further investigations may be warranted to exclude other conditions. Management of vitiligo involves a multidisciplinary approach, including topical therapies, phototherapy, surgical interventions, and psychological support. While repigmentation outcomes vary, advancements in targeted therapies and immunomodulatory agents hold promise for future treatment strategies. | ||
| Keywords | ||
| Vitiligo; Epidemiology; Etiology; Clinical Features; Types | ||
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