Nassar, M., Bebars, S., Said, R., Mustafa, T. (2019). Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Breast Cancer. test, 75(3), 2397-2405. doi: 10.21608/ejhm.2019.30955
Mahmoud Ismail Ahmed Nassar; Shaimaa M.M. Bebars; Rasha Mohamed Samir Said; Taghreed Mohammed Amin Mustafa. "Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Breast Cancer". test, 75, 3, 2019, 2397-2405. doi: 10.21608/ejhm.2019.30955
Nassar, M., Bebars, S., Said, R., Mustafa, T. (2019). 'Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Breast Cancer', test, 75(3), pp. 2397-2405. doi: 10.21608/ejhm.2019.30955
Nassar, M., Bebars, S., Said, R., Mustafa, T. Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Breast Cancer. test, 2019; 75(3): 2397-2405. doi: 10.21608/ejhm.2019.30955

Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Breast Cancer

The Egyptian Journal of Hospital Medicine
Article 12, Volume 75, Issue 3, April 2019, Pages 2397-2405    PDF (860.22 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.30955
Authors
Mahmoud Ismail Ahmed Nassar1; Shaimaa M.M. Bebars2; Rasha Mohamed Samir Said2; Taghreed Mohammed Amin Mustafa* 2
1Department of Pathology, Faculty of Medicine, Assiut University
2Department of Pathology, Faculty of Medicine, Aswan University
Abstract
Background: breast cancer (BC) is the most common type of diagnosed cancers in women. It is still the second leading cause of cancer-related death among women after lung cancer all over the world. Breast cancer is the first of top ten cancers in Egypt. It ranks as the first malignancy affecting females, contributing 30% of all female cancers. It affects 1 in 14 women during their life time. Aim: This study investigated the association between cyclooxygenase-2 (COX-2) expression in female breast cancer versus the expression of ER, PR, as well as its association with other established prognostic indicators like age, tumor size, lymph nodal status, stage, grade, lymphovascular invasion, insitu component and histological subtype, and aims to validate the role of overexpression of COX-2 as a prognostic marker in female patients with breast cancer in Egypt. Results: High significant correlation was found between lymph node metastasis, negative ER and PR cases and COX-2 expression. No significant correlation could be detected between age, tumor size, site, histologic type, grade, insitu component, LVI and COX-2 expression. Conclusion: Cyclooxygenase-2 has poor prognostic parameter in breast cancer, as it is over expressed in majority of breast carcinoma, especially with lymph node metastasis, ER and PR negative hormone receptor.
Keywords
breast cancer; Cyclooxygenase-2; prognostic marker; immunohistochemistry (IHC); ER\PR receptor; clincopathological data
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