Synthesis, Characterization and Study of Anti-Bacterial Activity of Some New Bis-Heterocyclic Derivatives | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Volume 15, Issue 2, December 2023, Pages 67-77 PDF (1.02 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2023.309591 | ||
| Authors | ||
| Hasan M. Marhoon; Ezzat H. Zimam | ||
| University of Kufa, Faculty of Science, Department of Chemistry, Al- Najaf / Iraq | ||
| Abstract | ||
| In this research, some new 1,2,3-triazole derivatives of dapsone, have been prepared. The first step includes the preparation of Azo derivative by reaction of dapsone with the 4-Aminoacetophenone to produce azo compounds (A), then, the amino group of dapsone is converted to a diazonium salt and reacted with sodium azide to obtain the compound (B) Then, Chalcones (D1-D3); has been prepared through the reaction of an aromatic ketone with different aldehydes. The second step involves the reaction of chalcones derivatives (D1-D3) with compound (B) in the presence of copper (I) to obtain a 1,2,3-triazoline compound (H5 – H7). Different spectroscopy methods, such as FT-IR, 1H-NMR, and 13C-NMR, were used to identify synthesized compounds. The potential antibacterial activity of the synthesized heterocyclic derivatives has been finally tested as a third stage, using two types of bacteria (Staphylococcus aureus and Escherichia coli). | ||
| Keywords | ||
| 1; 2; 3-triazole; dapsone; Anti-bacterial activity; Click chemistry | ||
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