Evaluation of reproductive capacity in adult male rats exposed to silver nanoparticles and the ameliorative role of lycopene | ||
| Journal of Scientific Research in Science | ||
| Articles in Press, Corrected Proof, Available Online from 26 July 2023 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jsrs.2023.216168.1111 | ||
| Author | ||
| Somia Rashed Fouad* | ||
| Zoology department, faculty of women, Ain Shams University, Cairo, Egypt. | ||
| Abstract | ||
| The present study was aimed to assess reproductive capacity of male albino rats exposed to silver nanoparticles (AgNPs) and the possible ameliorating role of lycopene (LYC). Twenty eight male albino rats were divided as follows: group I, received distilled water; group II received 100 mg/kg BW AgNPs; group III received 5 mg/kg BW LYC and group IV received both AgNPs+LYC at their same dosage. All doses were administrated orally and daily for 60 days. The results showed that AgNPs exposure decreased body weight gain as well as testicular and epididymal weight, reduced sperm count and induced sperm malformations. Histological findings revealed histo-morphometric change to the seminiferous tubules in AgNPs group. Biochemical investigation showed that AgNPs increased MDA level and decreased SOD, GSH and CAT levels in testicular tissue. Also it increased testicular ALP level and decreased testicular SDH level. Immuno-histochemical staining showed an increased caspase-3 and TNF-α expression in AgNPs group. Meanwhile, lycopene co-treated rats showed an improvement in body weight, testicular and epididymal weight changes, sperm characteristics, histological alterations, oxidative, inflammatory and apoptosis biomarkers. | ||
| Keywords | ||
| Reproductive toxicity; Silver nanoparticles; Lycopene; male albino rats | ||
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