Assessment of the Impact of Different Algorithms on the Radiotherapy Planning Quality for Breast Cancer Using the UK FAST Trial | ||
| SECI Oncology Journal | ||
| Volume 11, Issue 3, July 2023, Pages 200-206 | ||
| Abstract | ||
| Aim: Dose calculation algorithms play a pivotal role in assessing normal tissue toxicity and treatment outcomes during radiotherapy planning. Therefore, this study aimed to evaluate the Acuros External Beam (AXB) algorithm and Anisotropic Analytical Algorithm (AAA) for radiotherapy planning of left-sided breast cancer treatment with the UK FAST trial. Methods: A total of 100 treatment plans were retrospectively calculated with AAA and AXB algorithm for 50 patients with left-sided breast cancer at an early stage who received treatment with the UK FAST trial. The field angle, geometry, energy, beam segments, and prescription point were kept the same to avoid any bias when comparing algorithms. Results: The planning target volume (PTV) coverage parameters for AXB plans were higher than those for AAA plans, with a statistically significant difference in V90%, V105% and V107% between both calculation algorithms (p < 0.05). When comparing AXB with AAA calculated plans for the heart dosimetric parameters, the heart V25% for the AXB increased significantly, while the heart V5% was lower. The ipsilateral lung V30% and V15% of the AXB plans were significantly greater than those of the AAA plans. In contrast, the ipsilateral lung V5% decreased significantly. The AXB plans had a significantly increased average of 3% of the contralateral breast volume. Conclusion: It is important to use the efficient AXB algorithm to better estimate normal tissue toxicity and treatment outcomes in the treatment of breast cancer using the UK FAST trial. | ||
| Keywords | ||
| Acuros External Beam; Anisotropic Analytical Algorithm; UK FAST trial; Breast radiotherapy planning; Deep inspiration breath-hold | ||
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