Selim, I., Abdel Sattar, O., Abuseada, H., Emara, M., Serag, A. (2023). GREEN CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CIPROFLOXACIN, METRONIDAZOLE, AND INDOMETHACIN RESIDUES IN PHARMACEUTICAL INDUSTERIAL WASTEWATER EFFLUENTS. test, 67(1), 84-99. doi: 10.21608/ajps.2023.311248
Islam Selim; Osama Abdel Sattar; Hamed Abuseada; Mohamed Emara; Ahmed Serag. "GREEN CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CIPROFLOXACIN, METRONIDAZOLE, AND INDOMETHACIN RESIDUES IN PHARMACEUTICAL INDUSTERIAL WASTEWATER EFFLUENTS". test, 67, 1, 2023, 84-99. doi: 10.21608/ajps.2023.311248
Selim, I., Abdel Sattar, O., Abuseada, H., Emara, M., Serag, A. (2023). 'GREEN CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CIPROFLOXACIN, METRONIDAZOLE, AND INDOMETHACIN RESIDUES IN PHARMACEUTICAL INDUSTERIAL WASTEWATER EFFLUENTS', test, 67(1), pp. 84-99. doi: 10.21608/ajps.2023.311248
Selim, I., Abdel Sattar, O., Abuseada, H., Emara, M., Serag, A. GREEN CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CIPROFLOXACIN, METRONIDAZOLE, AND INDOMETHACIN RESIDUES IN PHARMACEUTICAL INDUSTERIAL WASTEWATER EFFLUENTS. test, 2023; 67(1): 84-99. doi: 10.21608/ajps.2023.311248

GREEN CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CIPROFLOXACIN, METRONIDAZOLE, AND INDOMETHACIN RESIDUES IN PHARMACEUTICAL INDUSTERIAL WASTEWATER EFFLUENTS

Al-Azhar Journal of Pharmaceutical Sciences
Volume 67, Issue 1, March and April 2023, Pages 84-99    PDF (732.36 K)
Document Type: Original Article
DOI: 10.21608/ajps.2023.311248
Authors
Islam Selim* 1; Osama Abdel Sattar2; Hamed Abuseada2; Mohamed Emara2, 3; Ahmed Serag2
1Department of Pharmaceutical Analytical Chemistry, School of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
2Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.
3Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt. 3 Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Menoufia University, Shebin Elkom, Egypt.
Abstract
Development and validation of three simple, eco-friendly, accurate and precise chemometric models have been presented for the spectrophotometric determination of ciprofloxacin (CIP), indomethacin (IND), and metronidazole (MET) residues in production wastewater samples. These methods are classical least square (CLS), principal component regression (PCR) and partial least square (PLS-1). A 3-factor 5-level experimental design was built leading to 25 mixtures containing different ratios of CIP, MET, and IND. Thirteen mixtures were used as a training set, and the other twelve were used as a validation set. Using of multi-wavelengths instead of the single wavelength spectrophotometry has greatly improved the precision and predictive abilities of these multivariate calibrations. The proposed methods have been found to be accurate, precise and can be used for determination of the drugs in pure form and industrial wastewater samples without preliminary separation steps. The methods described were used to accurately assess the drug residues in laboratory-prepared mixtures and actual industrial wastewater samples to confirm that it is free from these drug residues so it can be recycled and used for irrigation and other purposes.
Keywords
Ciprofloxacin; Indomethacin; Metronidazole; Chemometrics; Wastewater
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