1Biochemistry Department, Faculty of Vet. Med. Benha Univ., Egypt. | ||
| Benha Veterinary Medical Journal | ||
| Article 17, Volume 32, Issue 1, March 2017, Pages 99-103 PDF (327.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2017.31160 | ||
| Authors | ||
| Afaf D. Abdel Mageid1; Mohamed E.S Abou Salem1; Nancy Awad Salaam2 | ||
| 1Biochemistry Department, Faculty of Vet. Med. Benha Univ., Egypt | ||
| 2Department of Forensic medicine and toxicology, Faculty of Vet. Med. Benha Univ., Egypt | ||
| Abstract | ||
| The present study was to determine the effect of aged garlic extract (AGE) on alleviating diabetic cardiomyopathy (DCM) in rats. An experimental diabetic rat model was induced by a single dose (60mg/kg body weight) of I.P injection of streptozoticin (STZ). AGE was orally administrated at a dose of 500 mg/kg body weight. Metabolic profiles include serum glucose, insulin, total cholesterol and triacylglycerols and myocardial enzymes activities as creatine kinase-isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) were determined. The obtained results indicated that administration of AGE increased the body weight and insulin concentration, meanwhile, significant decrease in serum glucose concentration, CK-MB and LDH activities when compared with untreated induced diabetic group. Total cholesterol, triacylglycerols and AST showed non-significant changes in serum values in AGE treated diabetic rats in comparing with STZ-induced diabetic group. From the obtained results it could be concluded that, AGE has great potential therapeutic effect in the diabetic cardiomyopathy and other complications of coronary heart disease | ||
| Keywords | ||
| Diabetic cardiovascular diseases; aged garlic extract; myocardial enzymes | ||
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