The efficacy of the adipose tissue derived mesenchymal stem cells in the treatment of the lead acetate-induced nephrotoxicity in the adult male albino rats | ||
| Journal of Medical Histology | ||
| Article 6, Volume 6, Issue 1, June 2022, Pages 79-91 PDF (1.1 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmh.2023.204686.1115 | ||
| Author | ||
| Mohamed Abdel Rahman* | ||
| Department of Human Anatomy and Embryology, Sohag University, Sohag, Egypt | ||
| Abstract | ||
| Background and Objectives: Lead acetate is one of the heavy metals that causes food, water and air pollution. Exposure to lead acetate causes toxic effects on several body organs including the kidney. The adipose tissue contains multipotent mesenchymal stem cells that could be isolated and cultured on suitable media to proliferate and give large number of stem cells. When injected into a living animal body, these stem cells have the ability to migrate to the sites of the lesions to replace the destroyed cells. The aim of the present study was to evaluate the possibility of the adipose tissue derived mesenchymal stem cells (Ad-MSCs) to ameliorate the nephrotoxic effects of lead acetate. Materials and Methods: Fifty adult male albino rats were used in this work. Ten rats were used as a source of the Ad-MSCs and the other forty rats were used in the experimental study. These forty rats were randomly divided into four groups; group 1 (control group), group 2 (lead acetate-treated group) received lead acetate to induce nephrotoxicity, group 3 (recovery group) received lead acetate to induce nephrotoxicity then left for spontaneous recovery. Group 4 (Ad-MSCs-treated group) received lead acetate to induce nephrotoxicity then, receive the Ad-MSCs to induce renal recovery. Results: Lead acetate administration caused impaired renal function, disturbed renal oxidant/antioxidant status and histological renal destruction with insignificant spontaneous recovery. Administration of Ad-MSCs alleviated the biochemical and histological nephrotoxic effects of lead acetate. Conclusion: The Ad-MSCs have curative properties against the nephrotoxic effects caused by lead acetate. | ||
| Keywords | ||
| Lead acetate; nephrotoxicity; stem cells | ||
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