Left Ventricular Mass after Growth Hormone Replacement Therapy | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 91, Volume 92, Issue 1, July 2023, Pages 6062-6069 PDF (832.25 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2023.312351 | ||
| Abstract | ||
| Background: Adults with growth hormone deficiency (GHD) have a number of cardiovascular risk factors that may enhance their risk of cardiovascular morbidity and mortality. The impact of growth hormone (GH) therapy on heart function and metabolic abnormalities that may increase children's risk of cardiovascular disease (CVD) at an early age has been the subject of very few research in children. Aim: To evaluate the effect of growth hormone therapy on left ventricular mass. Patients and methods: This prospective cohort study was carried out at Pediatric Cardiology and Endocrinology Units of Children’s Hospital and Clinical Pathology Laboratory, Faculty of Medicine, Zagazig University. In total, 41 people took part while studying. Two groups were created out of them: those with idiopathic short stature, which included 16 children, and those with growth hormone insufficiency, which included 25 children. To determine LV mass, Echocardiography was used. Results: The left ventricular mass increased in a statistically meaningful way (from 83.4 g to 89.57 g) after GH therapy. Conclusion: LV mass increased remarkably in our patients after GH therapy .LV mass correlated positively with duration of GH therapy and negatively with the percentage of final height to lowest target height. | ||
| Keywords | ||
| Left ventricular mass; Growth hormone | ||
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