Serum Vitamin D Levels in Children with Immune Thrombocytopenia: Review Article | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 96, Volume 92, Issue 1, July 2023, Pages 6091-6094 PDF (434.66 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2023.312357 | ||
| Abstract | ||
| Background: Platelet disorders include immune thrombocytopenia (ITP). In ITP, the child's platelet count is too low, therefore blood does not clot normally. Small blood cells called platelets are produced in the bone marrow. Platelet degradation by antibodies and/or cells may have a role in ITP's pathophysiology, albeit this is not fully understood. Children who are newly diagnosed or chronic ITP type often have vitamin D (VD) deficiency. Since of this, immune cells that express VD nuclear receptor (VDR) are helpful because they can break down VD. Objective: Assessment of correlations of vitamin D Level among children who have immune thrombocytopenia. Methods: We scoured scholarly journals and information repositories including PubMed, Google Scholar, and Science Direct for studies on serum vitamin D levels and immune thrombocytopenia. Only the most recent or comprehensive study conducted between November 2001 and July 2020 was considered. The authors also analysed references from comparable works. As a result, non-English documents have been overlooked due to a lack of resources to translate them. Unpublished articles, oral presentations, conference abstracts, and dissertations were all generally agreed upon not to constitute legitimate scientific investigations. Conclusion: Among newly diagnosed ITP cases, especially in children, cytokine abnormalities have been identified. Literature on VD and ITP, pathogenesis and medical diagnosis is poorly reviewed. The use of VD can also be helpful for new diagnosed as well as chronic ITP patients. | ||
| Keywords | ||
| Immune thrombocytopenia; Children; Vitamin D | ||
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