The Value of Serum Hepciden level in Diagnosis of Anemia in Children with Chronic kidney Diseases | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 17 August 2023 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2023.220361.1443 | ||
| Authors | ||
| Amir Khalaf Mikhael* 1; naglaa makram farag2; Salah Mahmoud Saleh3; Ahlam Mohamed Ismail4 | ||
| 1Pediatric department faculty of medicine Minia university | ||
| 2alminya | ||
| 3Minia | ||
| 4Pediatrics, Midicine,Minia University | ||
| Abstract | ||
| Abstract: stract: Background: Anemia is a common complication in chronic kidney disease (CKD. Hepcidin, an acute phase protein in iron regulation, can provide information regarding iron homeostasis and anemia in chronic disease Aim of the work: to determine the cause of anemia in children with CKD by measuring the serum level of hepcidin. Methods: This study was carried out in Pediatric department in Minia University maternity & children hospital from Augest 2021 to February 2022. The study included 60 patients with clinical and laboratory confirmation Chronic Kidney Disease With anemia and 30 apparently healthy children of matchable age and sex Results: There was a significant difference in cases with CKD regarding weight and height [p value <0.001, when compared to their corresponding values in control healthy group. There is no significant difference in cases with CKD regarding age, gender, residence & BMI when compared to control group., that showed significantly lower growth parameters compared to controls . Hb, MCV, MCH, MCHC were significantly lower in cases, [p value <<0.001] when compared to their corresponding values in control group. Also, renal function tests Urea, creatinine and GFR were significantly higher in cases, [p value <0.001], when compared to values in control group. Elevated urea and creatinine would have independent effects of eGFR on the development of anemia by representing the accumulation of uremic toxins which could inhibit effective erythropoiesis. there was a significant elevation in ferritin and TIBC and significant decrease in iron in cases with CKD. | ||
| Keywords | ||
| Minia University hospital; chronic kidney disease; children. | ||
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