Some teratological effects of difloxacin in rats | ||
| Benha Veterinary Medical Journal | ||
| Article 30, Volume 30, Issue 1, March 2016, Pages 266-271 PDF (276.31 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2016.31373 | ||
| Authors | ||
| Ashraf Elkomy; Mohamed Aboubakr; Nermin Medhat | ||
| Department of Pharmacology, Faculty of Veterinary Medicine, Benha University | ||
| Abstract | ||
| The aim of this experiment was to detect the teratogenic effects of difloxacin in Wister Albino rats. Thirty pregnant rats were divided into 3 groups; group (1) behaved as control and received normal saline. Group (2) was administered difloxacin at a dose of 20 mg/kg b. wt and group (3) was administered difloxacin at a dose of 40 mg/kg b. wt orally once daily from 6th to 15th day of pregnancy. The study revealed no teratogenic effect at a dose of 20 mg/kg b. wt, while at a dose of 40 mg/kg b.wt has significant teratogenic effect showed by decrease in size, weight, length, retarded growth in fetuses, fetal resorption of treated groups, the incidences of skeletal & visceral abnormalities were increased in treated group (40 mg/kg b. wt). It could be concluded that. Administration of difloxacin during early stage of pregnancy and at high dose induce some fetal abnormalities. | ||
| Keywords | ||
| difloxacin; Pregnancy; Visceral and Skeletal Abnormalities | ||
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