Could Reticulocyte Haemoglobin Content (CHr) Help in Determination of Iron Status? Review article | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 121, Volume 92, Issue 1, July 2023, Pages 6256-6260 PDF (466.9 K) | ||
| DOI: 10.21608/ejhm.2023.314471 | ||
| Abstract | ||
| Background: Hemoglobin (Hb) carries oxygen throughout the body and is essential to survival, so maintaining healthy levels of Hb production is crucial. Due to their short lifespan (about 120 days), mature erythrocyte Hb is not a reliable indicator of Hb production. Objective: Review of the literature if Reticulocyte haemoglobin content (CHr) help in determination of iron status. Methods: We looked for data on Reticulocyte Haemoglobin Content in scholarly journals and databases including PubMed, Google Scholar, and Science Direct. The most recent or extensive studies published between October 2012 and August 2022 was taken into account. The writers also analysed similar works cited in their work. Lack of resources to translate documents written in languages other than English has led to their neglection. It was generally recognized that scientific research did not include research that was not published in a peer-reviewed journal, presented orally, or presented as a conference abstract or dissertation. Conclusion: CHr is unaffected by influences outside of iron metabolism and reflects the current state of Hb synthesis. In cases when it is challenging to estimate the ideal iron requirement, such as when providing an erythropoiesis-stimulating drug. CHr testing can help with the early detection of iron deficiency (ESA). Several investigations have shown that CHr detection in peripheral blood samples is a reliable method for identifying individuals with an iron shortage. It has been demonstrated to be a reliable indicator of iron status and a practical method for gauging the success of iron therapy. | ||
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