Clinico-pathological Features of Squamous Cell Carcinoma of Urinary Bladder at South Egypt Cancer Institute (Retrospective Study) | ||
| SECI Oncology Journal | ||
| Volume 11, Issue 3, July 2023, Pages 236-243 | ||
| Abstract | ||
| Objectives: The objective of this research is to determine the clinicopathological characteristics of bladder squamous cell carcinoma encountered over a ten year period in Radiation Oncology Department, South Egypt Cancer Institute, Assiut University. Methods: the medical records of bladder cancer cases during the period from 2008 to 2018 were retrospectively reviewed and tabulated. Results: A total of 62 urinary bladder cancer (UBC) cases were recorded. The mean age was 57.21 ± 7.44 years (range; 40-70) years. The male-to-female ratio was 3.4:1. The main clinical presentation was burning micturition in 46.8%, followed by hematuria in 37.1%, dysuria in 9.7%, and cystitis in 6.5%. The ECOG performance status of the study cases was also assessed and showed that; 85.5 % have PS Ⅰ, 11.3% have PS Ⅱ, and 3.2% have PS Ⅲ. Regarding tumor grade; almost all study cases (90.3%) have tumor grade Ⅱ, while 9.7% have tumor grade Ⅲ. Regarding tumor stage; 19.4%, 45.2%, 29.0%, and 6.5% had T1, T2, T3, and T4 respectively, and only one case suffered from positive nodal metastasis. Regarding treatment; 64.5% underwent radical cystectomy with uretero-cutaneous shunt, 22.6% underwent anterior pelvic excentration, 6.5% underwent partial cystectomy, and another 6.5% have bladder preservation. Patients who underwent radical cystectomy and partial cystectomy received neoadjuvant chemotherapy then underwent surgery and patients who underwent anterior pelvic excentration receive postoperative radiotherapy and patients refusing surgery underwent maximal TURBT then received concurrent chemoradiation. The median duration of follow up was 50 months (range; 5-171 months). According to Kaplan-Meier analysis, at five year the rate of OS was 79.2%. By the end of the study, 17.7% of patients had died of their cancer. A total of 6/62 patients (9.7%) developed disease recurrence. The median time to locoregional recurrence was 49 months (range, 4 to 171 months). According to Kaplan-Meier analysis, at five year the rate of DFS was 91.1%. There were 900 cases of bladder cancer attending to South Egypt Cancer Institute in the period from the 1st of January 2008 up to the end of December 2018; 62 of these patients met the criteria in our study. Conclusion: Bladder cancer is fairly common in our locality. SCC is generally, decreasing compared with TCC. This trend may be the outcome of improved bilharziasis control in rural Egyptian populations due to the use of potent oral antibilharzial medications. | ||
| Keywords | ||
| Bladder cancer; Squamous Cell Carcinoma; South Egypt Cancer Institute | ||
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