Comparative Study between Fat Injection and Platelet Rich Plasma in Post Burn Facial Scar:Clinical and Histological Assessment | ||
| The Egyptian Journal of Plastic and Reconstructive Surgery | ||
| Articles in Press, Accepted Manuscript, Available Online from 21 September 2023 | ||
| Document Type: Research article | ||
| DOI: 10.21608/ejprs.2023.233460.1294 | ||
| Authors | ||
| Wagdi Ali1; Abdelrahman Shehata* 2; Tarek Raief3; Mohamed Mostafa Elyounsi4; Dalia M.Badary5; youssef Saleh6 | ||
| 1Plasticsurgery department faculty of medicine assiut university | ||
| 2plastic surgery department ,faculty of medicine ,Assiut university | ||
| 3Plastic Surgery Department, Assiut university, Assiut, EGYPT | ||
| 4Plastic Surgery Department, Assiut University, Assiut, Egypt | ||
| 5pathologydepartment faculty of medicine assiut university | ||
| 6Plastic & Reconstructive surgery, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Abstract Background& aim: There is no widely approved treatment procedure for post-burn scars, even though many therapy approaches have been promoted. Many previous studies separately evaluated fat injection and platelet rich plasma in treatment of post-burn scar. This study aimed to compare efficacy of both fat injection and platelet rich plasma in improving outcome of post burn facial scar. Patients& Methods: In the current study a total of 60 patients with post-burn facial scar were enrolled. Those patients were randomly subdivided into either fat injection group (n= 30) or platelet rich plasma group (PRP) (n= 30). Baseline characteristics were recorded in addition to Vancouver score (VS) used to assess the scar and histological evaluation. Results: Most patients were female with no significant differences among both groups regarding different baseline data and scar characteristics. There were no significant differences among the groups regarding baseline vancouver score (VS) and epidermal thickness, but the fat injection group had significantly lower VS (3.67 ± 1.83 vs 3.87 ± 1.33; p < 0.001) and higher epidermal thickness (362.20 ± 92.73 vs. 255.40 ± 90.00 (um); p < 0.001) during follow-up. There were only two (6.7percent) cases in the PRP group & four (13.3%) cases in the fat injection group developed conservatively relieved edema. Conclusion: the autologous fat injection was effective and safe technique in improving the outcome of post-burn facial scar as evaluated by Vancouver score and epidermal thickness. It’s recommended to perform such study on large number of patients in multiple centers with longer duration of follow up to confirm such findings. | ||
| Keywords | ||
| Keywords: post-burn scar; Vancouver score; platelets rich plasma; fat injection | ||
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