Tumor Lymphocytic Infiltration as a Prognostic Factor in Gastric Carcinoma | ||
| SECI Oncology Journal | ||
| Volume 11, Issue 3, July 2023, Pages 260-274 | ||
| Abstract | ||
| Background: Gastric cancer has a relatively high prevalence and is one of the most common causes of cancer-related death worldwide. Despite many improvements in diagnosis and treatment, the prognosis for gastric cancer remains poor especially in the advanced stages. Several studies suggested that tumor lymphocytic infiltration (TLI) has a prognostic role in gastric carcinoma and may direct patient selection for immunotherapy. Our study aims to evaluate TLI in gastric carcinoma and its impact on survival. Material and Method: This was a cohort retrospective study involved 73 gastric carcinoma patients at South Egypt Cancer Institute, in period from the beginning of 2016 to the end of 2020 to evaluate the relation between TLI and clinicopathological features, and its impact on survival outcomes in gastric carcinoma patients. Results: Patients with high grade tumor, advanced stage, lymph node positive patients’ group and the presence of patient distant metastasis (M1) in the presence of low TLI density were significantly associated with poor OS(p=0.033), (p=0.014), (p=0.001) and (p=0.006), respectively. A borderline significance impact on OS was noted in patients who responded to treatment in the presence of high TLI (p=0.067). Conclusion: High TLI density has favorable outcome regarding OS in gastric carcinoma. These results may give us some valuable prognostic factors for medical management of gastric carcinoma. | ||
| Keywords | ||
| gastric carcinoma; tumor lymphocytic infiltration; prognostic factor; outcome | ||
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