EFFECT OF ANTIOXIDANT ON HEPATIC FATTY ACID PATTERN IN VITAMIN E-DEFICIENT RATS | ||
| Egyptian Journal of Agricultural Research | ||
| Article 26, Volume 79, Issue 2, July 2001, Pages 715-729 PDF (4.36 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejar.2001.318869 | ||
| Authors | ||
| SAEB A. HAFEZ1; SAMER A. ISMAEL2 | ||
| 1Special Food and Nutrition Department, Food Science and Technology Department, Faculty of Agriculture, Cairo University, Giza, Egypt | ||
| 2Biochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt | ||
| Abstract | ||
| The present investigation aims to find a proper answer whether can the antioxidant effect of vitamin E be substituted by the antioxidant effect of high levels of vitamin C. A or selenium Ion using the fatty acid pattern of liver as an indicator for lipid peroxidation?. Rats were fed o a standard diet containing vitamin E stripped cons or cotton seed oils for 49 days. Excess amounts of vitamin A (0.45 giclay). vitamin C (7.5 mg/ day), sodium selenito (0.1 mg/clay). or water were daily administered by a stomach tube. Normal rats led on diet containing corn or cotton seed oil for 6 weeks were used as control groups. Fatty acid composition of tho liver was determined by gas-liquid chromatography technique. There was . significant decrease in CI to in vitamin Egeticient corn oil group and it was completely absent in vitamin E-deficient cotton seed oil group with Increase the C16.0 and Ci a 1. Administration of vitamin A in the Presence of vitamin E-stripped cotton seed oil, gave satisfactory results by increasing of C15.2 and decreasing Of Ciao and Citi. White. in the Presence of vilemin &stripped corn oil, the autexidation of Cigo was increased. therefore Shen chain fatty acids were present relatively in large amounts compared to its control group (corn oil group). Administration of vitamin C in the presence of vitamin Elliippecl Corn oil Significantly increased hepatic Meant acid from Si% to 46.6% and oleic acid from 3.7% to 11.1%. Administration of Wend° ion to the sane group moderately increased,steanc. oleic and linoteic adds. &Nears ion was the best additive to vitamin E-stripped corn oil and it improved the pattern of fatty adds Containing eighteen carbon atoms (Ciao C15:1, C15.2). In the case of vitamin E-deltcient rats fed on cotton Seed oi Kw from vitamin E. administration of vitamin C or solonite ion gave the best results. in which, the fatty acid patterns beeline Similar to its control group (Colton seed oil groups). | ||
| Keywords | ||
| Vitamin E. A. C antioxidant. hepatic fatty acid pat- torn. lipid percoldation; stibnite ien | ||
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