Multifactorial Elements Affecting Bone Mineral Status and Growth in Children with Thalassemia Major | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Article 3, Volume 30, Issue 1, December 2017, Pages 23-33 PDF (758.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2017.763.1005 | ||
| Author | ||
| Eithar Karem El-Adham* | ||
| Radioisotope Department, Nuclear Research Center, Atomic Energy Authority, Egypt | ||
| Abstract | ||
| Aim: To determine the association of adipokynes like Leptin, Ghrelin, antioxidants as SOD, Glutathione, peroxidase and iron overload and their effect on growth and on bone mineral density in patients with thalassemia major Methods: 30 patients and 30 healthy age and sex matched controls from the hematology clinic hospital, Cairo University. Clinical examination and the anthropometric measurements are done in all subjects. Bone mineral density is assessed using DXA machine on lumbar spine expressed in Z Score Laboratory investigations, including super oxide dismutase (SOD) and Glutathione peroxidase. Results: The study showed that there was a significant difference between cases and controls regarding BMI, Leptin, Ghrelin, BMD, SOD and glutathione peroxides with p- values 0.003, | ||
| Keywords | ||
| beta thalassemia; leptin; ghrelin; antioxidants; BMD | ||
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