Gratification Phenomenon: Clinical Phenotype and Sex Hormones Profile | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 19, Volume 93, Issue 1, October 2023, Pages 7025-7033 PDF (417.2 K) | ||
| DOI: 10.21608/ejhm.2023.320369 | ||
| Abstract | ||
| Background: Self-gratification is characterized by self-stimulation of the genitalia habitually. Childhood masturbation could be described as genital stimulation and touching begins at the age of 2 months, although in certain cases, it may start as early as in-utero. It is of great difficulty to distinguish attacks of masturbation from different medical situations, which include fits, dyskinesia, infantile spasm and abdominal pain. Objective: To demonstrate the clinical and epidemiologic criteria of infant and child with gratification phenomenon and to assess the level of some sex hormones in such patients. Methods: This was case control study that conducted on 25 children diagnosed with self-gratification disorder with control group included 25 children of matched age and gender. Gratification phenomenon diagnosis in our patient was according to descriptive history and review of videotaped events. Laboratory investigation included level of dehydroepiandrosterone sulfate (DHEAS), 17-hydroxyprogesterone(17-OHP) and estradiol. Results: Regarding serum hormone levels, 17-OHP had comparable levels between the cases and control groups. However, both DHEAS and estradiol were significantly decreased in the cases in comparison with the control group. Serum DHEAS had a significant positive correlation with the age of the first attack, while estradiol had a significant negative correlation with attack frequency. Conclusion: Hormonal assay showed significant decline in serum DHEAS and estradiol levels in patients with gratification disorder but with normal levels of 17-OHP, this may indicate the potential role of this hormonal deficiency in pathogenesis of self-gratification phenomena. | ||
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