SOME STUDIES ON SHEEP VACCINATED WITH SMITHBURN ATTENUATED RIFT VALLEY FEVER VACCINE | ||
| Egyptian Journal of Agricultural Research | ||
| Article 26, Volume 79, Issue 3, September 2001, Pages 1141-1149 PDF (2.78 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejar.2001.320493 | ||
| Authors | ||
| KAREM E. Z. HASSAN; KHAIRAT A. ELIAN; MOHAMED M. TAHA | ||
| Veterinary Serum and Vaccine Research Institute, Agricultural Research Centre, Ministry of Agriculture, Dokki, Giza, Egypt | ||
| Abstract | ||
| This study was performed on 9 adult sheep divided into 3 groups, one group included nonpregnant vaccinated sheep, second group was pregnant vaccinated ewes and the third group was nonpregnant non-vaccinated kept as control. Some of the vaccinated animals showed a slight elevation of body temperature. Two pregnant ewes delivered normal lambs, while the 3rd ewe was aborted one month after vaccination. RVF virus was isolated from different organs of the aborted foetus. No significant changes were found in total protein, Serum Glutamic Oxaloacetic Transaminase (GOT) and Serum Pyrovic Transaminase (GPT) than values as compared with non-vaccinated control animals. However, there was significant decrease in albumin value and significant increase in globulin value than in control animals. The neutralizing antibodies were still detectable at protective level till 36 months post-vaccination and the peak was reached at the 3rd month post-vaccination. The immunoglobulins as detected by Enzyme Linked lmmunosorbent Assay (ELISA) were recorded as optical density reading and the results were correlated with those obtained by Serum Neutralization Test (SNT). | ||
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