Ragab, K., Bayoumi, L., Nassar, S., Abdelbary, A., Barghash, O. (2019). AUDA as a modulator of lipid profile and endothelial function in diet induced hypercholesterolemia in rats. test, 39(2), 204-215. doi: 10.21608/besps.2019.11996.1019
Kawkab Ragab; Lubna Bayoumi; Seham Zakaria Nassar; Amany Abdelbary; Ola Barghash. "AUDA as a modulator of lipid profile and endothelial function in diet induced hypercholesterolemia in rats". test, 39, 2, 2019, 204-215. doi: 10.21608/besps.2019.11996.1019
Ragab, K., Bayoumi, L., Nassar, S., Abdelbary, A., Barghash, O. (2019). 'AUDA as a modulator of lipid profile and endothelial function in diet induced hypercholesterolemia in rats', test, 39(2), pp. 204-215. doi: 10.21608/besps.2019.11996.1019
Ragab, K., Bayoumi, L., Nassar, S., Abdelbary, A., Barghash, O. AUDA as a modulator of lipid profile and endothelial function in diet induced hypercholesterolemia in rats. test, 2019; 39(2): 204-215. doi: 10.21608/besps.2019.11996.1019

AUDA as a modulator of lipid profile and endothelial function in diet induced hypercholesterolemia in rats

Bulletin of Egyptian Society for Physiological Sciences
Article 6, Volume 39, Issue 2, December 2019, Pages 204-215    PDF (546.94 K)
Document Type: Original Article
DOI: 10.21608/besps.2019.11996.1019
Authors
Kawkab Ragab1; Lubna Bayoumi1; Seham Zakaria Nassar* 2; Amany Abdelbary3; Ola Barghash1
1Department of medical physiology, faculty of medicine,Alexandria university, Alexandria, Egypt.
2Department of medical physiology, faculty of medicine, Alexandria university, Alexandria, Egypt
3Department of pathology, faculty of medicine,Alexandria university, Alexandria, Egypt.
Abstract
Background: Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid produced by the vascular endothelium and act as important regulators of vascular tone.
Objectives: to study the effect of soluble epoxide hydrolase inhibition AUDA on endothelial function in hypercholesterolemic rats.
Methods: Hypercholesterolemia was induced by using Matos diet for 8 weeks and it significantly increased TC, TG, and LDL-C and decreased HDL-C. AUDA, was used with a dose of 0.35 mg/ kg for 10 weeks via gastric gavage every other day.
Results: AUDA treated group has significantly lower total-C, TG, LDL-C and higher HDL-C as compared to untreated group. AUDA also improved vascular reactivity and vasodilatory response to different doses of Acetyl choline. Histopathological examination of aortic rings showed reduced development of atherosclerotic changes in the vascular wall with no effect on e-NOS expression in vascular endothelial cells.
Conclusions: We can conclude that AUDA treatment has improved lipid profile and protect against development of atherosclerotic histopathological changes.
Keywords
AUDA; endothelial dysfunction; Epoxyeicosatrienoic acids; Hypercholesterolemia; nitric oxide synthase (NOS)
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